Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR041298 is a DNA polymerase eta, ubiquitin-binding zinc finger.
<p>The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [[cite:PUB00094761], [cite:PUB00091153]]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [[cite:PUB00094763], [cite:PUB00091660], [cite:PUB00094767]], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [[cite:PUB00094758], [cite:PUB00094765]], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [[cite:PUB00041615], [cite:PUB00094762], [cite:PUB00094764]], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [[cite:PUB00094766], [cite:PUB00094760], [cite:PUB00094768]].</p> <p>This entry represents type 3 UBZ found in DNA polymerase eta ([ec:2.7.7.7]). It is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. The UBZ domain adopts a classical C2H2 zinc-finger structure characterized by a β-β-α fold [[cite:PUB00041615]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | DNA polymerase IV; TAIR: AT1G49980.1 DNA/RNA polymerases superfamily protein; Swiss-Prot: sp|P34409|POLK_CAEEL DNA polymerase kappa; TrEMBL-Plants: tr|I1LFP9|I1LFP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459700 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 100.00 |