Description

IPR041298 is a DNA polymerase eta, ubiquitin-binding zinc finger.

<p>The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [[cite:PUB00094761], [cite:PUB00091153]]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [[cite:PUB00094763], [cite:PUB00091660], [cite:PUB00094767]], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [[cite:PUB00094758], [cite:PUB00094765]], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [[cite:PUB00041615], [cite:PUB00094762], [cite:PUB00094764]], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [[cite:PUB00094766], [cite:PUB00094760], [cite:PUB00094768]].</p> <p>This entry represents type 3 UBZ found in DNA polymerase eta ([ec:2.7.7.7]). It is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. The UBZ domain adopts a classical C2H2 zinc-finger structure characterized by a β-β-α fold [[cite:PUB00041615]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: