Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR017961 is a DNA polymerase, Y-family, little finger domain.
<p>This entry represents the little finger domain found in Y-family (lesion bypass) DNA polymerases. Y-family polymerases were originally known as UmuC/DinB/Rev1/Rad30 after each branch of the family. These enzymes are characterised by their low-fidelity synthesis on undamaged DNA templates and by their ability to traverse replication-blocking lesions. By contrast, high-fidelity polymerases (such as DNA polymerase III) are sensitive to distortions in the DNA template. As a result, Y-family polymerases can extend primer strands across DNA strand lesions that would otherwise stall replicative polymerases. To minimize mutations through their low fidelity synthesis, these enzymes are regulated, and are thought to interact with processivity factors, β-clamp or proliferating cell nuclear antigen (PCNA), which are also essential for the function of replicative DNA polymerases [[cite:PUB00031831]]. Organisms can contain more than one Y-family polymerase, each with a unique DNA damage bypass and fidelity profile. For example, humans posses four Y-family polymerases: DNA polymerases kappa, iota, eta and Rev1. Y-family polymerases show no homology to DNA polymerases from the A-, B-, C-, D- or X-families [[cite:PUB00026570]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1| | 25 | ||
| – | PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1| | 25 | ||
| – | PREDICTED: DNA polymerase eta-like isoform X3 [Cicer arietinum] gi|502141797|ref|XP_004504643.1| | 15 | ||
| – | PREDICTED: DNA polymerase eta-like isoform X3 [Cicer arietinum] gi|502141797|ref|XP_004504643.1| | 15 | ||
| – | DNA polymerase IV; TAIR: AT1G49980.1 DNA/RNA polymerases superfamily protein; Swiss-Prot: sp|P34409|POLK_CAEEL DNA polymerase kappa; TrEMBL-Plants: tr|I1LFP9|I1LFP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459700 | 24 | ||
| – | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 29 | ||
| – | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 29 | ||
| – | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 26 | ||
| – | DNA polymerase IV; TAIR: AT5G44740.2 Y-family DNA polymerase H; Swiss-Prot: sp|Q8H2D5|POLH_ARATH DNA polymerase eta; TrEMBL-Plants: tr|I1KRK8|I1KRK8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055000 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |