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IPR001126 is a UmuC domain.
<p>In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [[cite:PUB00010596]]. UmuC is a well conserved protein in prokaryotes, with a homologue in yeast species.</p> <p>Proteins known to contain an UmuC domain are listed below:</p> <ul> <li>E. coli MucB protein. Plasmid-born analogue of the UmuC protein.</li> <li>Saccharomyces cerevisiae (Baker's yeast) Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents.</li> <li>Salmonella typhimurium ImpB protein. Plasmid-born analogue of the UmuC protein.</li> <li>Bacterial UmuC protein.</li> <li>E. coli DNA-damage-inducible protein P (DinP).</li> <li>S. typhimurium SamB homologue of UmuC plasmid associated.</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1| | 25 | ||
| – | PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1| | 25 | ||
| – | PREDICTED: DNA polymerase kappa-like [Cicer arietinum] gi|502158892|ref|XP_004511315.1| | 8 | ||
| – | PREDICTED: DNA polymerase eta-like isoform X3 [Cicer arietinum] gi|502141797|ref|XP_004504643.1| | 8 | ||
| – | PREDICTED: DNA polymerase eta-like isoform X3 [Cicer arietinum] gi|502141797|ref|XP_004504643.1| | 15 | ||
| – | PREDICTED: DNA polymerase eta-like isoform X3 [Cicer arietinum] gi|502141797|ref|XP_004504643.1| | 15 | ||
| – | DNA polymerase IV; TAIR: AT1G49980.1 DNA/RNA polymerases superfamily protein; Swiss-Prot: sp|P34409|POLK_CAEEL DNA polymerase kappa; TrEMBL-Plants: tr|I1LFP9|I1LFP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459700 | 24 | ||
| – | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 29 | ||
| – | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 29 | ||
| – | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 26 | ||
| – | DNA polymerase IV; TAIR: AT5G44740.2 Y-family DNA polymerase H; Swiss-Prot: sp|Q8H2D5|POLH_ARATH DNA polymerase eta; TrEMBL-Plants: tr|I1KRK8|I1KRK8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055000 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |