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IPR041507 is a Peptidase C12, C-terminal domain.
<p>This is the C-terminal domain found in eukaryotic UCH37 proteins (also known as Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCHL5). UCH37 is a subunit of two complexes: INO80, which performs ATP-dependent sliding of nucleosomes for transcriptional regulation and DNA repair, and the 26S proteasome, which performs ATP-dependent proteolysis of polyubiquitylated proteins in the cytosol and nucleus. Recruitment to the proteasome is mediated by the C-terminal domain of RPN13 (also known as ADRM1). Recruitment to INO80 is mediated by the N-terminal domain of NFRKB. Structural and biochemical analysis reveal that RPN13 and NFRKB make similar interactions with the UCH37 C-terminal domain but have very different interactions with the catalytic UCH domain that are activating in the case of RPN13 and highly inhibitory in the case of NFRKB [[cite:PUB00091602]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ubiquitin carboxyl-terminal hydrolase; TAIR: AT1G65650.1 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1; Swiss-Prot: sp|O04482|UCH2_ARATH Ubiquitin carboxyl-terminal hydrolase 2; TrEMBL-Plants: tr|I1NIJ5|I1NIJ5_SOYBN Ubiquitin carboxyl-terminal hydrolase; Found in the gene: LotjaGi5g1v0203800 | 16 | ||
| – | Ubiquitin carboxyl-terminal hydrolase; TAIR: AT1G65650.1 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1; Swiss-Prot: sp|O04482|UCH2_ARATH Ubiquitin carboxyl-terminal hydrolase 2; TrEMBL-Plants: tr|I1NIJ5|I1NIJ5_SOYBN Ubiquitin carboxyl-terminal hydrolase; Found in the gene: LotjaGi5g1v0203800 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd09617 | CDD | 1 | 50.00 |