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IPR041743 is a Bifunctional aspartokinase/homoserine dehydrogenase, N-terminal catalytic domain.
<p>This entry includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK-homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-HSDHI, ThrA and E. coli AKII-HSDHII, MetL) and higher plants (Z. mays AK-HSDH). AK and HSDH are the first and third enzymes in the biosynthetic pathway of the aspartate family of amino acids. AK catalyzes the phosphorylation of Asp to P-aspartyl phosphate. HSDH catalyzes the NADPH-dependent conversion of Asp 3-semialdehyde to homoserine. ThrA and MetL are involved in threonine and methionine biosynthesis, respectively. In E. coli, ThrA is subject to allosteric regulation by the end product L-threonine and the native enzyme is reported to be tetrameric. As with bacteria, plant AK and HSDH are feedback inhibited by pathway end products. Maize AK-HSDH is a Thr-sensitive 180kDa enzyme. Arabidopsis AK-HSDH is an alanine-activated, threonine-sensitive enzyme whose ACT domains, located C-terminal to the AK catalytic domain, were shown to be involved in allosteric activation [[cite:PUB00091747], [cite:PUB00091748], [cite:PUB00091749], [cite:PUB00091750], [cite:PUB00091751], [cite:PUB00091752], [cite:PUB00014809], [cite:PUB00017147]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Aspartokinase-homoserine dehydrogenase; TAIR: AT4G19710.2 aspartate kinase-homoserine dehydrogenase ii; Swiss-Prot: sp|P37142|AKH_DAUCA Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I1K3R3|I1K3R3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0370400 | 33 | ||
| – | Aspartokinase-homoserine dehydrogenase; TAIR: AT4G19710.2 aspartate kinase-homoserine dehydrogenase ii; Swiss-Prot: sp|O81852|AKH2_ARATH Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; TrEMBL-Plants: tr|A0A0B2PX90|A0A0B2PX90_GLYSO Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic; Found in the gene: LotjaGi4g1v0370400 | 33 | ||
| – | Aspartokinase-homoserine dehydrogenase; TAIR: AT4G19710.2 aspartate kinase-homoserine dehydrogenase ii; Swiss-Prot: sp|O81852|AKH2_ARATH Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; TrEMBL-Plants: tr|G7JAT7|G7JAT7_MEDTR Aspartokinase-homoserine dehydrogenase; Found in the gene: LotjaGi6g1v0041900 | 34 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04922 | CDD | 1 | 33.33 |