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IPR042036 is a Ribosomal RNA-processing protein 8, N-terminal domain.
<p>Ribosomal RNA processing protein 8 (Rrp8) is a nucleolar Rossman-fold like methyltransferase. In yeast, it is involved in pre-rRNA cleavage at site A2 [[cite:PUB00078607]] and is responsible for a base methylation of the 25S rRNA [[cite:PUB00078606]]. In humans it is also known as nucleomethylin (NML), and it is important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which regulates rRNA transcription in response to glucose deprivation [[cite:PUB00078608]]. NML represses rDNA transcription by promoting H3K9 methylation and establishing heterochromatin across the rDNA [[cite:PUB00050320]].</p> <p>This superfamily represents the N-terminal domain of the ribosomal RNA-processing protein 8 (RRP8).</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ribosomal RNA-processing protein 8; TAIR: AT5G40530.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q84JC0|RRP8_ARATH Ribosomal RNA-processing protein 8; TrEMBL-Plants: tr|I3T493|I3T493_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0611800 | 10 | ||
| – | Ribosomal RNA-processing protein 8; TAIR: AT5G40530.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q84JC0|RRP8_ARATH Ribosomal RNA-processing protein 8; TrEMBL-Plants: tr|I3T493|I3T493_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0611800 | 10 | ||
| – | Ribosomal RNA-processing protein 8; TAIR: AT5G40530.4 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q84JC0|RRP8_ARATH Ribosomal RNA-processing protein 8; TrEMBL-Plants: tr|I3T493|I3T493_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0611800 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |