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IPR042460 is a DCN1-like, PONY binding domain.
<p>This superfamily represents a domain is found in DCN1-like proteins. Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [[cite:PUB00021043], [cite:PUB00057468]].</p> <p>The structure of this domain is composed entirely of α helices [[cite:PUB00047735], [cite:PUB00050725]]. It has been referred to as potentiating neddylation domain (PONY) and can be found in association with an N-terminal UBA domain. The PONY domain contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [[cite:PUB00050725], [cite:PUB00064019]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Defective in cullin neddylation protein; TAIR: AT1G15860.1 defective in cullin neddylation protein (DUF298); Swiss-Prot: sp|Q92564|DCNL4_HUMAN DCN1-like protein 4; TrEMBL-Plants: tr|I3SMJ5|I3SMJ5_LOTJA Defective in cullin neddylation protein; Found in the gene: LotjaGi3g1v0351400 | 11 | ||
– | Defective in cullin neddylation protein; TAIR: AT1G15860.1 defective in cullin neddylation protein (DUF298); Swiss-Prot: sp|Q5PPL2|DCNL5_RAT DCN1-like protein 5; TrEMBL-Plants: tr|I1MTX5|I1MTX5_SOYBN Defective in cullin neddylation protein; Found in the gene: LotjaGi4g1v0284100 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 50.00 |