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IPR014764 is a Defective-in-cullin neddylation protein.
<p>The eukaryotic defective in cullin neddylation (DCN) protein family, contributes to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [[cite:PUB00021043], [cite:PUB00064019], [cite:PUB00097937]]. Proteins in the DCN family include:</p> <ul> <li>Yeast DCN1.</li> <li>Vertebrate DCN1-like protein 1-5.</li> <li>Plant Defective in cullin neddylation protein AAR3 [[cite:PUB00097939]].</li> </ul> <p>DCN family proteins all contain a Potentiating neddylation (PONY) domain ([interpro:IPR005176]), contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [[cite:PUB00050725], [cite:PUB00064019]]. The N-terminal region of the protein often contains a UBA-like domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DCN1-like protein 5-like [Glycine max] gi|356562876|ref|XP_003549694.1| | 8 | ||
| – | PREDICTED: DCN1-like protein 4-like isoform X1 [Cicer arietinum] gi|502174435|ref|XP_004515517.1| | 7 | ||
| – | PREDICTED: DCN1-like protein 5-like [Glycine max] gi|356562876|ref|XP_003549694.1| | 8 | ||
| – | PREDICTED: DCN1-like protein 2-like [Glycine max] gi|356531764|ref|XP_003534446.1| | 5 | ||
| – | PREDICTED: DCN1-like protein 2-like [Glycine max] gi|356525740|ref|XP_003531481.1| | 10 | ||
| – | PREDICTED: DCN1-like protein 2-like [Glycine max] gi|356525740|ref|XP_003531481.1| | 10 | ||
| – | Defective in cullin neddylation protein; TAIR: AT3G28970.1 defective in cullin neddylation protein (DUF298); Swiss-Prot: sp|Q6PH85|DCNL2_HUMAN DCN1-like protein 2; TrEMBL-Plants: tr|I3SK46|I3SK46_LOTJA Defective in cullin neddylation protein; Found in the gene: LotjaGi1g1v0504100 | 7 | ||
| – | Defective in cullin neddylation protein; TAIR: AT3G12760.1 defective in cullin neddylation protein; Swiss-Prot: sp|Q8BZJ7|DCNL2_MOUSE DCN1-like protein 2; TrEMBL-Plants: tr|I3SDD7|I3SDD7_LOTJA Defective in cullin neddylation protein; Found in the gene: LotjaGi3g1v0133600 | 11 | ||
| – | Defective in cullin neddylation protein; TAIR: AT1G15860.1 defective in cullin neddylation protein (DUF298); Swiss-Prot: sp|Q92564|DCNL4_HUMAN DCN1-like protein 4; TrEMBL-Plants: tr|I3SMJ5|I3SMJ5_LOTJA Defective in cullin neddylation protein; Found in the gene: LotjaGi3g1v0351400 | 11 | ||
| – | Defective in cullin neddylation protein; TAIR: AT1G15860.1 defective in cullin neddylation protein (DUF298); Swiss-Prot: sp|Q5PPL2|DCNL5_RAT DCN1-like protein 5; TrEMBL-Plants: tr|I1MTX5|I1MTX5_SOYBN Defective in cullin neddylation protein; Found in the gene: LotjaGi4g1v0284100 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |