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IPR043216 is a Phosphatidate (PA) phosphatase-related.
<p>This entry represents a group of membrane-associated phosphatidic acid phosphatases and their homologues mostly found in metazoa, fungi and plants.</p> <p>In budding yeasts there are two members, Lpp1 and Dpp1. Lpp1 catalyzes the Mg(2+)-independent dephosphorylation of phosphatidate (PA), diacylglycerol pyrophosphate (DGPP), and lysophosphatidate (LPA) [[cite:PUB00099544]]. Dpp1, a zinc-regulated enzyme that catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG) [[cite:PUB00099543]].</p> <p>In humans, the members are phospholipid phosphatase 1-5 (PLPP1-5) and phospholipid phosphatase-related protein type 1-5 (PLPR1-5). PLPPs are magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters [[cite:PUB00099545], [cite:PUB00099546], [cite:PUB00068994]]. PLPR1-5 may not have 2-lysophosphatidate/LPA phosphatase activity due to the lacking of critical residues supporting the reaction mechanism in active phosphatases of this phosphoesterase family.</p> <p>Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity [[cite:PUB00068984]]. Another lipid phosphate phosphatase (LPP) homologue, Wunen, is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors [[cite:PUB00099542]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. | ||
| Molecular function | Phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Lipid phosphate phosphatase-like protein; TAIR: AT3G02600.1 lipid phosphate phosphatase 3; Swiss-Prot: sp|Q8LFD1|LPP3_ARATH Putative lipid phosphate phosphatase 3, chloroplastic; TrEMBL-Plants: tr|A0A072UC91|A0A072UC91_MEDTR Lipid phosphate phosphatase-like protein; Found in the gene: LotjaGi1g1v0546100 | 15 | ||
| – | Lipid phosphate phosphatase-like protein; TAIR: AT3G02600.1 lipid phosphate phosphatase 3; Swiss-Prot: sp|Q8LFD1|LPP3_ARATH Putative lipid phosphate phosphatase 3, chloroplastic; TrEMBL-Plants: tr|A0A0R0L1F3|A0A0R0L1F3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0546100 | 14 | ||
| – | Lipid phosphate phosphatase-like protein; TAIR: AT1G15080.1 lipid phosphate phosphatase 2; Swiss-Prot: sp|Q9XI60|LPP2_ARATH Lipid phosphate phosphatase 2; TrEMBL-Plants: tr|V7C7M9|V7C7M9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0273500 | 14 | ||
| – | Lipid phosphate phosphatase-like protein; TAIR: AT2G01180.1 phosphatidic acid phosphatase 1; Swiss-Prot: sp|Q9ZU49|LPP1_ARATH Lipid phosphate phosphatase 1; TrEMBL-Plants: tr|K7MQ68|K7MQ68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0117700 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03390 | CDD | 1 | 25.00 |