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IPR036938 is a Phosphatidic acid phosphatase type 2/haloperoxidase superfamily.
<p>This entry represents type 2 phosphatidic acid phosphatase (PAP2; [ec:3.1.3.4]) enzymes, such as phosphatidylglycerophosphatase B [ec:3.1.3.27] from Escherichia coli. PAP2 enzymes have a core structure consisting of a 5-helical bundle, where the beginning of the third helix binds the cofactor [[cite:PUB00024099]]. PAP2 enzymes catalyse the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate [[cite:PUB00036051]]. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signalling molecules that are related to phosphatidate.</p> <p>Other related enzymes have a similar core structure, including haloperoxidases such as bromoperoxidase (contains one core bundle, but forms a dimer), chloroperoxidases (contains two core bundles arranged as in other family dimers), bacitracin transport permease from Bacillus licheniformis, glucose-6-phosphatase from rat. The vanadium-dependent haloperoxidases exclusively catalyse the oxidation of halides, and act as histidine phosphatases, using histidine for the nucleophilic attack in the first step of the reaction [[cite:PUB00010620]]. Amino acid residues involved in binding phosphate/vanadate are conserved between the two families, supporting a proposal that vanadium passes through a tetrahedral intermediate during the reaction mechanism.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Lipid phosphate phosphatase-like protein; TAIR: AT3G02600.1 lipid phosphate phosphatase 3; Swiss-Prot: sp|Q8LFD1|LPP3_ARATH Putative lipid phosphate phosphatase 3, chloroplastic; TrEMBL-Plants: tr|A0A072UC91|A0A072UC91_MEDTR Lipid phosphate phosphatase-like protein; Found in the gene: LotjaGi1g1v0546100 | 15 | ||
| – | Lipid phosphate phosphatase-like protein; TAIR: AT3G02600.1 lipid phosphate phosphatase 3; Swiss-Prot: sp|Q8LFD1|LPP3_ARATH Putative lipid phosphate phosphatase 3, chloroplastic; TrEMBL-Plants: tr|A0A0R0L1F3|A0A0R0L1F3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0546100 | 14 | ||
| – | Dihydrosphingosine 1-phosphate phosphatase; TAIR: AT3G58490.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|Q9M2G7|LPPD_ARATH Lipid phosphate phosphatase delta; TrEMBL-Plants: tr|I1JQE7|I1JQE7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0743200 | 13 | ||
| – | Lipid phosphate phosphatase-like protein; TAIR: AT1G15080.1 lipid phosphate phosphatase 2; Swiss-Prot: sp|Q9XI60|LPP2_ARATH Lipid phosphate phosphatase 2; TrEMBL-Plants: tr|V7C7M9|V7C7M9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0273500 | 14 | ||
| – | Phosphatidic acid phosphatase family protein, putative; TAIR: AT5G66450.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|Q6NQL6|LPPE2_ARATH Lipid phosphate phosphatase epsilon 2, chloroplastic; TrEMBL-Plants: tr|I3T9U8|I3T9U8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0387500 | 11 | ||
| – | Phosphatidic acid phosphatase family protein, putative; TAIR: AT5G66450.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|Q6NQL6|LPPE2_ARATH Lipid phosphate phosphatase epsilon 2, chloroplastic; TrEMBL-Plants: tr|I3T9U8|I3T9U8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0387500 | 12 | ||
| – | Phosphatidic acid phosphatase family protein, putative; TAIR: AT5G66450.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|Q6NQL6|LPPE2_ARATH Lipid phosphate phosphatase epsilon 2, chloroplastic; TrEMBL-Plants: tr|I3T9U8|I3T9U8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0387500 | 11 | ||
| – | Phosphatidic acid phosphatase family protein, putative; TAIR: AT3G50920.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|F4J220|LPPE1_ARATH Lipid phosphate phosphatase epsilon 1, chloroplastic; TrEMBL-Plants: tr|I3S350|I3S350_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0120200 | 8 | ||
| – | Phosphatidic acid phosphatase family protein, putative; TAIR: AT5G66450.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|Q6NQL6|LPPE2_ARATH Lipid phosphate phosphatase epsilon 2, chloroplastic; TrEMBL-Plants: tr|I3S350|I3S350_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0120200 | 12 | ||
| – | Lipid phosphate phosphatase 1; TAIR: AT5G03080.1 Phosphatidic acid phosphatase (PAP2) family protein; Swiss-Prot: sp|Q6NLA5|LPPG_ARATH Lipid phosphate phosphatase gamma, chloroplastic; TrEMBL-Plants: tr|A0A151T2M4|A0A151T2M4_CAJCA Dolichyldiphosphatase 1; Found in the gene: LotjaGi5g1v0075900 | 15 | ||
| – | Lipid phosphate phosphatase-like protein; TAIR: AT2G01180.1 phosphatidic acid phosphatase 1; Swiss-Prot: sp|Q9ZU49|LPP1_ARATH Lipid phosphate phosphatase 1; TrEMBL-Plants: tr|K7MQ68|K7MQ68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0117700 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03390 | CDD | 1 | 9.09 |