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PF10018

Source: Pfam

Description

Vitamin-D-receptor interacting Mediator subunit 4

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003712
Molecular function Transcription coregulator activity A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
Subterm of
GO:0006357
Biological process Regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
Subterm of
Regulates
GO:0016592
Cellular component Mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Subterm of

Associated Lotus transcripts 13

Transcript Name Description Predicted domains Domain count
Lj3g3v1487120.1
– PREDICTED: mediator of RNA polymerase II transcription subunit 4-like isoform X1 [Cicer arietinum] gi|502146174|ref|XP_004506336.1|
Domains
5
Lj4g3v1037660.1
–
Domains
5
Lj4g3v1037670.1
– PREDICTED: mediator of RNA polymerase II transcription subunit 4-like isoform X1 [Cicer arietinum] gi|502146174|ref|XP_004506336.1|
Domains
5
Lj5g3v0614970.1
– PREDICTED: mediator of RNA polymerase II transcription subunit 4-like isoform X1 [Cicer arietinum] gi|502146174|ref|XP_004506336.1|
Domains
5
LotjaGi3g1v0300100.1
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi3g1v0300100
Domains
4
LotjaGi3g1v0300100.2
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi3g1v0300100
Domains
4
LotjaGi3g1v0300100.3
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi3g1v0300100
Domains
4
LotjaGi4g1v0128200.1
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi4g1v0128200
Domains
4
LotjaGi4g1v0128200.2
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi4g1v0128200
Domains
4
LotjaGi5g1v0070200.1
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi5g1v0070200
Domains
4
LotjaGi5g1v0070200.2
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi5g1v0070200
Domains
4
LotjaGi5g1v0070200.3
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi5g1v0070200
Domains
4
LotjaGi5g1v0070200.4
– Mediator of RNA polymerase II transcription subunit 4; TAIR: AT5G02850.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q9LZ00|MED4_ARATH Mediator of RNA polymerase II transcription subunit 4; TrEMBL-Plants: tr|G7LC42|G7LC42_MEDTR Vitamin-D-receptor interacting mediator subunit 4; Found in the gene: LotjaGi5g1v0070200
Domains
4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.69