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GO:0000445

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description THO complex part of transcription export complex
Full defintion The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
Subterm of

Relationships

The relationship of GO:0000445 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCkrc
PMID
Genes with internal repeats require the THO complex for transcription.Voynov V, Verstrepen KJ, Jansen A, Runner VM, Buratowski S, Fink GR
Proc Natl Acad Sci U S A. 2006 Sep 26; 103 (39): 14423–8.PMID: 16983072

The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes, is required for the efficient expression of FLO11 and other yeast genes that have long internal tandem repeats. FLO11 transcription elongation in Tho- mutants is hindered in the region of the tandem repeats, resulting in a loss of function. Moreover, the repeats become genetically unstable in Tho- mutants. A FLO11 gene without the tandem repeats is transcribed equally well in Tho+ or Tho- strains. The Tho- defect in transcription is suppressed by overexpression of topoisomerase I, suggesting that the THO complex functions to rectify aberrant structures that arise during transcription.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj6g3v1995980.1
– PREDICTED: THO complex subunit 7 homolog isoform X1 [Cicer arietinum] gi|502078212|ref|XP_004485873.1|
GO terms
2
LotjaGi6g1v0324900.1
– THO complex subunit 7 like; TAIR: AT5G16790.1 Tho complex subunit 7/Mft1p; Swiss-Prot: sp|Q8LDS5|THO7A_ARATH THO complex subunit 7A; TrEMBL-Plants: tr|A0A0L9VF74|A0A0L9VF74_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0324900
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006397
Biological process MRNA processing 1 50.00