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Field | Value |
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Namespace | Cellular component |
Short description | Eukaryotic translation elongation factor 1 complex |
Full defintion | A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. |
Subterm of |
The relationship of GO:0005853 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0005853, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | jl |
PMID | Translational infidelity and human cancer: role of the PTI-1 oncogene. Int J Biochem Cell Biol. 1999 Jan; 31 (1): 151–62.PMID: 10216950 Several components of the eukaryotic protein synthesis apparatus have been associated with oncogenic transformation of cells. Altered expression of translation elongation factor 1 alpha (EF-1 alpha), a core component of protein synthesis and closely related sequences have been linked with transformed phenotypes by several independent studies, in diverse systems. A dominant acting oncogene, prostate tumor inducing gene-1 (PTI-1) has provided further evidence for this link. PTI-1 appears to be a hybrid molecule with components derived from both prokaryotic and eukaryotic origins. The predicted protein coding moiety represents an EF-1 alpha molecule, truncated N-terminal to amino acid residue 68 and having six additional point mutations. This coding sequence is fused to a 5' untranslated region (UTR) showing strongest homology to ribosomal RNA derived from Mycoplasma hyopneumoniae. Expression studies using the cloned cDNA in nude mouse tumor formation assays have confirmed the oncogenic nature of the molecule. A broad spectrum of tumor derived cell lines, from varied tissue sources and blood samples from patients having confirmed prostate carcinoma, all scored positive for expression of PTI-1, while corresponding normal tissues or blood samples were negative. Based on its near identity to EF-1 alpha, it is proposed that PTI-1 represents a new class of oncogene whose transforming capacity probably arises through mechanisms including: (i) protein translational infidelity, resulting in the synthesis of mutant polypeptides due to loss of proofreading function during peptide chain elongation, (ii) by its association with and alteration of the cytoskeleton, (iii) by impinging on one particular or several different signal transduction pathways through its properties as a G-protein. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: elongation factor 1-delta 2-like isoform X1 [Cicer arietinum] gi|502148510|ref|XP_004507191.1| | 3 | ||
– | PREDICTED: elongation factor 1-delta 2-like isoform X1 [Cicer arietinum] gi|502148510|ref|XP_004507191.1| | 3 | ||
– | Elongation factor 1-beta [Medicago truncatula] gi|357493769|ref|XP_003617173.1| | 3 | ||
– | Elongation factor 1-beta; TAIR: AT2G18110.1 Translation elongation factor EF1B/ribosomal protein S6 family protein; Swiss-Prot: sp|P93447|EF1D_PIMBR Elongation factor 1-delta; TrEMBL-Plants: tr|I3T5W1|I3T5W1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0222400 | 3 | ||
– | Elongation factor 1-beta 1; TAIR: AT5G12110.1 elongation factor 1-beta 1; Swiss-Prot: sp|Q84WM9|EF1B1_ARATH Elongation factor 1-beta 1; TrEMBL-Plants: tr|I3SIG0|I3SIG0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0187900 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Translational elongation | 1 | 20.00 |