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Field | Value |
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Namespace | Biological process |
Short description | Response to ionizing radiation |
Full defintion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. |
Subterm of |
The relationship of GO:0010212 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0010212, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | AtATM is essential for meiosis and the somatic response to DNA damage in plants. Plant Cell. 2003 Jan; 15 (1): 119–32.PMID: 12509526 In contrast to yeast or mammalian cells, little is known about the signaling responses to DNA damage in plants. We previously characterized AtATM, an Arabidopsis homolog of the human ATM gene, which is mutated in ataxia telangiectasia, a chromosome instability disorder. The Atm protein is a protein kinase whose activity is induced by DNA damage, particularly DNA double-strand breaks. The phosphorylation targets of Atm include proteins involved in DNA repair, cell cycle control, and apoptosis. Here, we describe the isolation and functional characterization of two Arabidopsis mutants carrying a T-DNA insertion in AtATM. Arabidopsis atm mutants are hypersensitive to gamma-radiation and methylmethane sulfonate but not to UV-B light. In correlation with the radiation sensitivity, atm mutants failed to induce the transcription of genes involved in the repair and/or detection of DNA breaks upon irradiation. In addition, atm mutants are partially sterile, and we show that this effect is attributable to abundant chromosomal fragmentation during meiosis. Interestingly, the transcription of DNA recombination genes during meiosis was not dependent on AtATM, and meiotic recombination occurred at the same rate as in wild-type plants, raising questions about the function of AtAtm during meiosis in plants. Our results demonstrate that AtATM plays a central role in the response to both stress-induced and developmentally programmed DNA damage. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
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– | PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase ATM-like [Cicer arietinum] gi|502133902|ref|XP_004501929.1| | 6 | ||
– | Serine/threonine-protein kinase; TAIR: AT3G48190.2 Serine/Threonine-kinase ATM-like protein; Swiss-Prot: sp|Q9M3G7|ATM_ARATH Serine/threonine-protein kinase ATM; TrEMBL-Plants: tr|A0A0R0KG32|A0A0R0KG32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0180100 | 6 | ||
– | LIM domain-containing protein A, putative isoform 1; TAIR: AT5G52950.1 LIM domain protein; Swiss-Prot: sp|Q7N125|SGRR_PHOLL HTH-type transcriptional regulator SgrR; TrEMBL-Plants: tr|G7LBX4|G7LBX4_MEDTR Uncharacterized protein; Found in the gene: LotjaGi3g1v0553200 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Mitotic DNA replication checkpoint | 1 | 33.33 |