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Field | Value |
---|---|
Namespace | Molecular function |
Short description | Lipoate synthase activity |
Full defintion | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. |
Subterm of |
The relationship of GO:0016992 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0016992, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
EC | 2.8.1.8 |
PMID | The Radical SAM Superfamily. Crit Rev Biochem Mol Biol. 2008 Jan-Feb; 43 (1): 63–88.PMID: 18307109 The radical S-adenosylmethionine (SAM) superfamily currently comprises more than 2800 proteins with the amino acid sequence motif CxxxCxxC unaccompanied by a fourth conserved cysteine. The charcteristic three-cysteine motif nucleates a [4Fe-4S] cluster, which binds SAM as a ligand to the unique Fe not ligated to a cysteine residue. The members participate in more than 40 distinct biochemical transformations, and most members have not been biochemically characterized. A handful of the members of this superfamily have been purified and at least partially characterized. Significant mechanistic and structural information is available for lysine 2,3-aminomutase, pyruvate formate-lyase, coproporphyrinogen III oxidase, and MoaA required for molybdopterin biosynthesis. Biochemical information is available for spore photoproduct lyase, anaerobic ribonucleotide reductase activation subunit, lipoyl synthase, and MiaB involved in methylthiolation of isopentenyladenine-37 in tRNA. The radical SAM enzymes biochemically characterized to date have in common the cleavage of the [4Fe-4S](1 +) -SAM complex to [4Fe-4S](2 +)-Met and the 5' -deoxyadenosyl radical, which abstracts a hydrogen atom from the substrate to initiate a radical mechanism. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: lipoyl synthase 2, mitochondrial-like [Glycine max] gi|356543805|ref|XP_003540350.1| | 4 | ||
– | PREDICTED: lipoyl synthase, chloroplastic-like [Glycine max] gi|356575490|ref|XP_003555873.1| | 4 | ||
– | Lipoyl synthase; TAIR: AT2G20860.1 lipoic acid synthase 1; Swiss-Prot: sp|B7FM45|LIAS_MEDTR Lipoyl synthase, mitochondrial; TrEMBL-Plants: tr|V7BWP4|V7BWP4_PHAVU Lipoyl synthase, mitochondrial; Found in the gene: LotjaGi3g1v0441800 | 4 | ||
– | Lipoyl synthase; TAIR: AT5G08415.1 Radical SAM superfamily protein; Swiss-Prot: sp|B9RX57|LISC_RICCO Lipoyl synthase, chloroplastic; TrEMBL-Plants: tr|A0A0R4J646|A0A0R4J646_SOYBN Lipoyl synthase, chloroplastic; Found in the gene: LotjaGi5g1v0345100 | 3 | ||
– | Lipoyl synthase; TAIR: AT5G08415.1 Radical SAM superfamily protein; Swiss-Prot: sp|B9RX57|LISC_RICCO Lipoyl synthase, chloroplastic; TrEMBL-Plants: tr|A0A0R4J646|A0A0R4J646_SOYBN Lipoyl synthase, chloroplastic; Found in the gene: LotjaGi5g1v0345100 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Molecular function | 4 iron, 4 sulfur cluster binding | 1 | 20.00 |