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GO:0031262

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Ndc80 complex
Full defintion A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.
Subterm of

Relationships

The relationship of GO:0031262 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Kinetochore-spindle microtubule interactions during mitosis.Kline-Smith SL, Sandall S, Desai A
Curr Opin Cell Biol. 2005 Feb; 17 (1): 35–46.PMID: 15661517

The kinetochore is a proteinaceous structure that assembles onto centromeric DNA and mediates chromosome attachment to microtubules during mitosis. This description is deceivingly simple: recent proteomic studies suggest that the diminutive kinetochores of Saccharomyces cerevisiae are comprised of at least 60 proteins organized into as many as 14 different subcomplexes. Many of these proteins, such as the centromeric histone variant CENP-A, and entire subcomplexes, such as the Ndc80(Hec1) complex, are conserved from yeast to humans despite the diverse nature of the DNA sequences on which they assemble. There have recently been advances in our understanding of the molecular basis of how kinetochores establish dynamic attachments to spindle microtubules, and how these attachments are correctly oriented to ensure segregation of sister chromatids to daughter cells.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0355069.1
– PREDICTED: kinetochore protein NDC80 homolog [Glycine max] gi|356557509|ref|XP_003547058.1|
GO terms
2
Lj4g3v2693610.1
– PREDICTED: kinetochore protein nuf2-like [Cicer arietinum] gi|502140318|ref|XP_004504164.1|
GO terms
2
LotjaGi6g1v0357700.1
– Kinetochore NDC80-like protein; TAIR: AT3G54630.1 kinetochore protein; Swiss-Prot: sp|O14777|NDC80_HUMAN Kinetochore protein NDC80 homolog; TrEMBL-Plants: tr|I1MDQ7|I1MDQ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0357700
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0051315
Biological process Attachment of mitotic spindle microtubules to kinetochore 1 33.33