Gene Ontology — View

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GO:0031932

Overview

Field	Value
Namespace	Cellular component
Short description	TORC2 complex
Full defintion	A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
Subterm of	GO:0032991 GO:0038201

Relationships

The relationship of GO:0031932 with other GO terms.

Relationship type	GO terms
Is a	GO:0032991 GO:0038201
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0031932, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	jh
PMID	Amino acid signaling in TOR activation.Kim J, Guan KL Annu Rev Biochem. 2011; 80 (): 1001–32.PMID: 21548787 The target of rapamycin (TOR) is a central cell growth regulator conserved from yeast to mammals. Uncontrolled TOR activation is commonly observed in human cancers. TOR forms two distinct structural and functional complexes, TORC1 and TORC2. TORC1 promotes cell growth and cell size by stimulating protein synthesis. A wide range of signals, including nutrients, energy levels, and growth factors, are known to control TORC1 activity. Among them, amino acids (AA) not only potently activate TORC1 but are also required for TORC1 activation by other stimuli, such as growth factors. The mechanisms of growth factors and cellular energy status in activating TORC1 have been well elucidated, whereas the molecular basis of AA signaling is just emerging. Recent advances in the role of AA signaling on TORC1 activation have revealed key components, including the Rag GTPases, protein kinases, nutrient transporters, and the intracellular trafficking machinery, in relaying AA signals to TORC1 activation.

Field

Value

GOC

PMID

Amino acid signaling in TOR activation.Kim J, Guan KL
Annu Rev Biochem. 2011; 80 (): 1001–32.PMID: 21548787

The target of rapamycin (TOR) is a central cell growth regulator conserved from yeast to mammals. Uncontrolled TOR activation is commonly observed in human cancers. TOR forms two distinct structural and functional complexes, TORC1 and TORC2. TORC1 promotes cell growth and cell size by stimulating protein synthesis. A wide range of signals, including nutrients, energy levels, and growth factors, are known to control TORC1 activity. Among them, amino acids (AA) not only potently activate TORC1 but are also required for TORC1 activation by other stimuli, such as growth factors. The mechanisms of growth factors and cellular energy status in activating TORC1 have been well elucidated, whereas the molecular basis of AA signaling is just emerging. Recent advances in the role of AA signaling on TORC1 activation have revealed key components, including the Rag GTPases, protein kinases, nutrient transporters, and the intracellular trafficking machinery, in relaying AA signals to TORC1 activation.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
LotjaGi6g1v0320200.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	WD40 repeat-like protein; TAIR: AT3G18140.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp\|Q54D08\|LST8_DICDI Protein LST8 homolog; TrEMBL-Plants: tr\|I3S6V4\|I3S6V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0320200	GO terms View details of GO:0031929 View details of GO:0031931 View details of GO:0031932	3
LotjaGi6g1v0320200.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	WD40 repeat-like protein; TAIR: AT3G18140.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp\|Q54D08\|LST8_DICDI Protein LST8 homolog; TrEMBL-Plants: tr\|I3S6V4\|I3S6V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0320200	GO terms View details of GO:0031929 View details of GO:0031931 View details of GO:0031932	3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0031932 View details of GO:0031932 AmiGO InterPro QuickGO	Cellular component	TORC2 complex	1	50.00