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GO:0032977

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Membrane insertase activity
Full defintion Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family.
Subterm of

Relationships

The relationship of GO:0032977 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Escherichia coli YidC is a membrane insertase for Sec-independent proteins.Serek J, Bauer-Manz G, Struhalla G, van den Berg L, Kiefer D, Dalbey R, Kuhn A
EMBO J. 2004 Jan 28; 23 (2): 294–301.PMID: 14739936

YidC is a recently discovered bacterial membrane protein that is related to the mitochondrial Oxa1p and the Alb3 protein of chloroplasts. These proteins are required in the membrane integration process of newly synthesized proteins that do not require the classical Sec machinery. Here we demonstrate that YidC is sufficient for the membrane integration of a Sec-independent protein. Microgram amounts of the purified single-spanning Pf3 coat protein were efficiently inserted into proteoliposomes containing the purified YidC. A mutant Pf3 coat protein with an extended hydrophobic region was inserted independently of YidC into the membrane both in vivo and in vitro, but its insertion was accelerated by YidC. These results show that YidC can function separately from the Sec translocase to integrate membrane proteins into the lipid bilayer.

Associated Lotus transcripts 11

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0065769.1
– PREDICTED: ALBINO3-like protein 1, chloroplastic-like [Glycine max] gi|356569211|ref|XP_003552798.1|
GO terms
2
Lj0g3v0065789.1
– PREDICTED: ALBINO3-like protein 1, chloroplastic-like [Glycine max] gi|356569211|ref|XP_003552798.1|
GO terms
2
Lj0g3v0223399.1
– PREDICTED: mitochondrial inner membrane protein OXA1-like [Glycine max] gi|356548765|ref|XP_003542770.1|
GO terms
2
Lj1g3v2809410.1
– PREDICTED: ALBINO3-like protein 2, chloroplastic-like [Glycine max] gi|356566939|ref|XP_003551682.1|
GO terms
2
Lj1g3v2809410.2
– PREDICTED: ALBINO3-like protein 2, chloroplastic-like [Glycine max] gi|356566939|ref|XP_003551682.1|
GO terms
2
Lj3g3v3188540.1
– PREDICTED: inner membrane protein PPF-1, chloroplastic-like [Glycine max] gi|356539022|ref|XP_003537999.1|
GO terms
2
LotjaGi1g1v0483300.1
– Membrane protein insertase YidC; TAIR: AT3G44370.1 Membrane insertion protein, OxaA/YidC with tetratricopeptide repeat domain-containing protein; Swiss-Prot: sp|Q0WUC5|ALB33_ARATH ALBINO3-like protein 3, mitochondrial; TrEMBL-Plants: tr|K7MUF6|K7MUF6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0483300
GO terms
2
LotjaGi2g1v0178100.1
– Membrane protein insertase YidC; TAIR: AT5G62050.1 inner membrane OXA1-like protein; Swiss-Prot: sp|Q42191|OXA1_ARATH Mitochondrial inner membrane protein OXA1; TrEMBL-Plants: tr|K7M0E7|K7M0E7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0178100
GO terms
2
LotjaGi2g1v0178200_LC.1
– Mitochondrial inner membrane protein OXA1; TAIR: AT5G62050.1 inner membrane OXA1-like protein; Swiss-Prot: sp|Q42191|OXA1_ARATH Mitochondrial inner membrane protein OXA1; TrEMBL-Plants: tr|A0A0R0J5G3|A0A0R0J5G3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0178200_LC
GO terms
2
LotjaGi2g1v0371800.1
– Membrane protein insertase YidC; TAIR: AT2G28800.1 63 kDa inner membrane family protein; Swiss-Prot: sp|Q9FY06|PPF1_PEA Inner membrane protein PPF-1, chloroplastic; TrEMBL-Plants: tr|A0A0B2QQI6|A0A0B2QQI6_GLYSO Inner membrane protein PPF-1, chloroplastic; Found in the gene: LotjaGi2g1v0371800
GO terms
2
LotjaGi6g1v0097300.1
– Membrane protein insertase YidC; TAIR: AT1G24490.1 OxaA/YidC-like membrane insertion protein; Swiss-Prot: sp|Q9FYL3|ALB31_ARATH ALBINO3-like protein 1, chloroplastic; TrEMBL-Plants: tr|I1MYL3|I1MYL3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0097300
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0032977
Molecular function Membrane insertase activity 1 9.09