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GO:0042284

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Sphingolipid delta-4 desaturase activity
Full defintion Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid.
Subterm of

Relationships

The relationship of GO:0042284 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
A new class of lipid desaturase central to sphingolipid biosynthesis and signalling.Napier JA, Michaelson LV, Dunn TM
Trends Plant Sci. 2002 Nov; 7 (11): 475–8.PMID: 12417141

Sphingolipids and their phosphorylated metabolites play crucial roles in intracellular signalling in animals, and evidence is emerging for analogous situations in fungi and plants. Central to this signalling pathway is the phosphorylation of the sphingoid long chain base, sphingosine, which yields sphingosine-1-phosphate. Until recently, the enzyme responsible for the biosynthesis of sphingosine was unknown, but the Delta(4)-long chain base desaturase that carries out this reaction has now been identified. Orthologues are present in animals, plants and fungi, raising the possibility of using reverse genetics to determine the contribution of sphingosine-1-phosphate to signalling networks.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj6g3v2043190.1
– PREDICTED: sphingolipid delta(4)-desaturase DES1-like [Cicer arietinum] gi|502077808|ref|XP_004485750.1|
GO terms
3
LotjaGi6g1v0333400.1
– Sphingolipid delta-4 desaturase; TAIR: AT4G04930.1 fatty acid desaturase family protein; Swiss-Prot: sp|Q6H5U3|DES1L_ORYSJ Sphingolipid delta(4)-desaturase DES1-like; TrEMBL-Plants: tr|I3SQJ0|I3SQJ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0333400
GO terms
3
LotjaGi6g1v0333400.2
– Sphingolipid delta-4 desaturase; TAIR: AT4G04930.1 fatty acid desaturase family protein; Swiss-Prot: sp|Q6H5U3|DES1L_ORYSJ Sphingolipid delta(4)-desaturase DES1-like; TrEMBL-Plants: tr|I3SQJ0|I3SQJ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0333400
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0042284
Molecular function Sphingolipid delta-4 desaturase activity 1 33.33