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GO:0043162

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Full defintion The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
Subterm of

Relationships

The relationship of GO:0043162 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCjl
PMID
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.Katzmann DJ, Babst M, Emr SD
Cell. 2001 Jul 27; 106 (2): 145–55.PMID: 11511343

The multivesicular body (MVB) pathway is responsible for both the biosynthetic delivery of lysosomal hydrolases and the downregulation of numerous activated cell surface receptors which are degraded in the lysosome. We demonstrate that ubiquitination serves as a signal for sorting into the MVB pathway. In addition, we characterize a 350 kDa complex, ESCRT-I (composed of Vps23, Vps28, and Vps37), that recognizes ubiquitinated MVB cargo and whose function is required for sorting into MVB vesicles. This recognition event depends on a conserved UBC-like domain in Vps23. We propose that ESCRT-I represents a conserved component of the endosomal sorting machinery that functions in both yeast and mammalian cells to couple ubiquitin modification to protein sorting and receptor downregulation in the MVB pathway.

Associated Lotus transcripts 1

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi1g1v0277000.1
– Proline-rich cell wall-like protein; TAIR: AT5G53330.1 Ubiquitin-associated/translation elongation factor EF1B protein; Swiss-Prot: sp|Q9NZ09|UBAP1_HUMAN Ubiquitin-associated protein 1; TrEMBL-Plants: tr|I3SQZ2|I3SQZ2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0277000
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0043162
Biological process Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 1 100.00