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GO:0045145

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Single-stranded DNA 5'-3' exodeoxyribonuclease activity
Full defintion Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.
Subterm of

Relationships

The relationship of GO:0045145 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCelh
PMID
Yeast exonuclease 5 is essential for mitochondrial genome maintenance.Burgers PM, Stith CM, Yoder BL, Sparks JL
Mol Cell Biol. 2010 Mar; 30 (6): 1457–66.PMID: 20086101

Yeast exonuclease 5 is encoded by the YBR163w (DEM1) gene, and this gene has been renamed EXO5. It is distantly related to the Escherichia coli RecB exonuclease class. Exo5 is localized to the mitochondria, and EXO5 deletions or nuclease-defective EXO5 mutants invariably yield petites, amplifying either the ori3 or ori5 region of the mitochondrial genome. These petites remain unstable and undergo continuous rearrangement. The mitochondrial phenotype of exo5Delta strains suggests an essential role for the enzyme in DNA replication and recombination. No nuclear phenotype associated with EXO5 deletions has been detected. Exo5 is a monomeric 5' exonuclease that releases dinucleotides as products. It is specific for single-stranded DNA and does not hydrolyze RNA. However, Exo5 has the capacity to slide across 5' double-stranded DNA or 5' RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.

Associated Lotus transcripts 7

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0360189.2
– PREDICTED: probable exonuclease V-like [Glycine max] gi|356539114|ref|XP_003538045.1|
GO terms
1
Lj3g3v2309700.1
– PREDICTED: probable exonuclease V-like [Glycine max] gi|356539114|ref|XP_003538045.1|
GO terms
1
Lj3g3v2309700.2
– PREDICTED: probable exonuclease V-like [Glycine max] gi|356539114|ref|XP_003538045.1|
GO terms
1
Lj5g3v2166180.1
– PREDICTED: exonuclease V, chloroplastic-like [Cicer arietinum] gi|502120509|ref|XP_004496985.1|
GO terms
1
Lj5g3v2166190.1
–
GO terms
1
LotjaGi2g1v0363200.1
– Exonuclease V-like protein; TAIR: AT5G60370.1 exonuclease V-like protein; Swiss-Prot: sp|Q9FKK6|EXO5_ARATH Exonuclease V, chloroplastic; TrEMBL-Plants: tr|I1LKD2|I1LKD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0363200
GO terms
1
LotjaGi3g1v0365000.1
– Exonuclease V-like protein; TAIR: AT5G60370.1 exonuclease V-like protein; Swiss-Prot: sp|Q9FKK6|EXO5_ARATH Exonuclease V, chloroplastic; TrEMBL-Plants: tr|V7AF84|V7AF84_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0365000
GO terms
1

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0045145
Molecular function Single-stranded DNA 5'-3' exodeoxyribonuclease activity 1 14.29