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Field | Value |
---|---|
Namespace | Molecular function |
Short description | Pectinesterase inhibitor activity |
Full defintion | Stops, prevents or reduces the activity of any pectinesterase enzyme. |
Subterm of |
The relationship of GO:0046910 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0046910, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | ai |
PMID | Kiwi protein inhibitor of pectin methylesterase amino-acid sequence and structural importance of two disulfide bridges. Eur J Biochem. 2000 Jul; 267 (14): 4561–5.PMID: 10880981 A protein acting as a powerful inhibitor of plant pectin methylesterase was isolated from kiwi (Actinidia chinensis) fruit. The complete amino-acid sequence of the pectin methylesterase inhibitor (PMEI) was determined by direct protein analysis. The sequence comprises 152 amino-acid residues, accounting for a molecular mass of 16 277 Da. The far-UV CD spectrum indicated a predominant alpha-helix conformation in the secondary structure. The protein has five cysteine residues but neither tryptophan nor methionine. Analysis of fragments obtained after digestion of the protein alkylated without previous reduction identified two disulfide bridges connecting Cys9 with Cys18, and Cys74 with Cys114; Cys140 bears a free thiol group. A database search pointed out a similarity between PMEI and plant invertase inhibitors. In particular, the four Cys residues, which in PMEI are involved in the disulfide bridges, are conserved. This allows us to infer that also in the homologous proteins, whose primary structure was deduced only by cDNA sequencing, those cysteine residues are engaged in two disulfide bridges, and constitute a common structural motif. The comparison of the sequence of these inhibitors confirms the existence of a novel class of proteins with moderate but significant sequence conservation, comprising plant proteins acting as inhibitors of sugar metabolism enzymes, and probably involved in various steps of plant development. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Pectin methylesterase inhibitor; TAIR: AT1G48020.1 pectin methylesterase inhibitor 1; Swiss-Prot: sp|Q9LNF2|PMEI1_ARATH Pectinesterase inhibitor 1; TrEMBL-Plants: tr|A0A151R4S4|A0A151R4S4_CAJCA Pectinesterase inhibitor; Found in the gene: LotjaGi2g1v0185500 | 2 | ||
– | Pectin methylesterase inhibitor; TAIR: AT1G48020.1 pectin methylesterase inhibitor 1; Swiss-Prot: sp|P83326|PMEI_ACTDE Pectinesterase inhibitor; TrEMBL-Plants: tr|A0A151SPC0|A0A151SPC0_CAJCA Pectinesterase inhibitor 1; Found in the gene: LotjaGi2g1v0185700 | 2 | ||
– | Pectin methylesterase inhibitor; TAIR: AT1G48020.1 pectin methylesterase inhibitor 1; Swiss-Prot: sp|P83326|PMEI_ACTDE Pectinesterase inhibitor; TrEMBL-Plants: tr|A0A151SPC0|A0A151SPC0_CAJCA Pectinesterase inhibitor 1; Found in the gene: LotjaGi3g1v0033100 | 2 | ||
– | Invertase/pectin methylesterase inhibitor family protein; TAIR: AT1G48020.1 pectin methylesterase inhibitor 1; Swiss-Prot: sp|P83326|PMEI_ACTDE Pectinesterase inhibitor; TrEMBL-Plants: tr|A0A151SPC0|A0A151SPC0_CAJCA Pectinesterase inhibitor 1; Found in the gene: LotjaGi3g1v0033300 | 2 | ||
– | Pectin methylesterase inhibitor; TAIR: AT3G17220.1 pectin methylesterase inhibitor 2; Swiss-Prot: sp|P83326|PMEI_ACTDE Pectinesterase inhibitor; TrEMBL-Plants: tr|A0A1J7HS69|A0A1J7HS69_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0172400 | 2 | ||
– | Invertase/pectin methylesterase inhibitor family protein; TAIR: AT1G48020.1 pectin methylesterase inhibitor 1; Swiss-Prot: sp|P83326|PMEI_ACTDE Pectinesterase inhibitor; TrEMBL-Plants: tr|A0A1J7HS69|A0A1J7HS69_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0023800 | 2 | ||
– | Pectinesterase inhibitor; TAIR: AT5G64620.1 cell wall / vacuolar inhibitor of fructosidase 2; Swiss-Prot: sp|P83326|PMEI_ACTDE Pectinesterase inhibitor; TrEMBL-Plants: tr|A9P9N2|A9P9N2_POPTR Uncharacterized protein; Found in the gene: LotjaGi6g1v0279800 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Molecular function | Pectinesterase inhibitor activity | 1 | 14.29 |