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GO:0051499

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description D-aminoacyl-tRNA deacylase activity
Full defintion Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA.
Subterm of

Relationships

The relationship of GO:0051499 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0051499, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
D-Amino acids and D-Tyr-tRNA(Tyr) deacylase: stereospecificity of the translation machine revisited.Yang H, Zheng G, Peng X, Qiang B, Yuan J
FEBS Lett. 2003 Sep 25; 552 (2-3): 95–8.PMID: 14527667

Until 30 years ago, it had been considered that D-amino acids were excluded from living systems except for D-amino acids in the cell wall of microorganisms. However, D-amino acids, in the form of free amino acids, peptides and proteins, were recently detected in various living organisms from bacteria to mammals. The extensive distribution of bio-functional D-amino acids challenges the current concept of protein synthesis: more attention should be paid to the stereospecificity of the translation machine. Besides aminoacyl-tRNA synthetases, elongation factor Tu and some other mechanisms, D-Tyr-tRNA(Tyr) deacylases provide a novel checkpoint since they specifically recycle misaminoacylated D-Tyr-tRNA(Tyr) and some other D-aminoacyl-tRNAs. Their unique structure represents a new class of tRNA-dependent hydrolase. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origin.

Associated Lotus transcripts 9

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0050309.1
– D-aminoacyl-tRNA deacylase [Medicago truncatula] gi|357516879|ref|XP_003628728.1|
GO terms
3
Lj0g3v0203889.1
– D-aminoacyl-tRNA deacylase [Medicago truncatula] gi|357516879|ref|XP_003628728.1|
GO terms
2
Lj0g3v0203889.2
– PREDICTED: D-aminoacyl-tRNA deacylase-like [Cicer arietinum] gi|502155086|ref|XP_004509954.1|
GO terms
2
Lj4g3v1108080.1
– D-aminoacyl-tRNA deacylase [Medicago truncatula] gi|357516879|ref|XP_003628728.1|
GO terms
2
Lj6g3v2006180.1
– PREDICTED: D-tyrosyl-tRNA(Tyr) deacylase-like [Glycine max] gi|356555390|ref|XP_003546015.1|
GO terms
3
LotjaGi4g1v0168400.1
– D-aminoacyl-tRNA deacylase; TAIR: AT2G03800.2 D-aminoacyl-tRNA deacylase; Swiss-Prot: sp|Q9ZPQ3|GEK1_ARATH D-aminoacyl-tRNA deacylase; TrEMBL-Plants: tr|I3SP65|I3SP65_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0168400
GO terms
2
LotjaGi4g1v0168400.2
– D-aminoacyl-tRNA deacylase; TAIR: AT2G03800.2 D-aminoacyl-tRNA deacylase; Swiss-Prot: sp|Q9ZPQ3|GEK1_ARATH D-aminoacyl-tRNA deacylase; TrEMBL-Plants: tr|I3SP65|I3SP65_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0168400
GO terms
3
LotjaGi6g1v0326000.1
– D-aminoacyl-tRNA deacylase; TAIR: AT4G18460.1 D-Tyr-tRNA(Tyr) deacylase family protein; Swiss-Prot: sp|Q54EY1|DTD_DICDI D-tyrosyl-tRNA(Tyr) deacylase; TrEMBL-Plants: tr|A0A0S3S2V1|A0A0S3S2V1_PHAAN D-tyrosyl-tRNA(Tyr) deacylase; Found in the gene: LotjaGi6g1v0326000
GO terms
3
LotjaGi6g1v0326000.2
– D-aminoacyl-tRNA deacylase; TAIR: AT4G18460.1 D-Tyr-tRNA(Tyr) deacylase family protein; Swiss-Prot: sp|Q54EY1|DTD_DICDI D-tyrosyl-tRNA(Tyr) deacylase; TrEMBL-Plants: tr|A0A0L9VFL8|A0A0L9VFL8_PHAAN D-tyrosyl-tRNA(Tyr) deacylase; Found in the gene: LotjaGi6g1v0326000
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0051499
Molecular function D-aminoacyl-tRNA deacylase activity 1 11.11