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GO:0002161

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Aminoacyl-tRNA editing activity
Full defintion The hydrolysis of an incorrectly aminoacylated tRNA.
Subterm of

Relationships

The relationship of GO:0002161 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOChjd
PMID
Molecular basis of alanine discrimination in editing site.Sokabe M, Okada A, Yao M, Nakashima T, Tanaka I
Proc Natl Acad Sci U S A. 2005 Aug 16; 102 (33): 11669–74.PMID: 16087889

AlaX is the homologue of the class II alanyl-tRNA synthetase editing domain and has been shown to exhibit autonomous editing activity against mischarged tRNA(Ala). Here, we present the structures of AlaX from the archaeon Pyrococcus horikoshii in apo form, complexed with zinc, and with noncognate amino acid l-serine and zinc. Together with mutational analysis, we demonstrated that the conserved Thr-30 hydroxyl group located near the beta-methylene of the bound serine is responsible for the discrimination of noncognate serine from cognate alanine, based on their chemical natures. Furthermore, we confirmed that the conserved Gln-584 in alanyl-tRNA synthetase, which corresponds to Thr-30 of AlaX, is also critical for discrimination. These observations strongly suggested conservation of the chemical discrimination among trans- and cis-editing of tRNA(Ala).

Associated Lotus transcripts 56

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0034749.1
– PREDICTED: prolyl-tRNA synthetase associated domain-containing protein 1-like [Fragaria vesca subsp]. vesca] gi|470109114|ref|XP_004290847.1|
GO terms
1
Lj0g3v0034779.1
–
GO terms
1
Lj0g3v0034789.1
– 25.7 kDa protein [Cicer arietinum] gi|7271117|emb|CAB81546.1|
GO terms
1
Lj0g3v0034799.1
–
GO terms
1
Lj0g3v0063869.1
– PREDICTED: valine--tRNA ligase-like [Cicer arietinum] gi|502091866|ref|XP_004489655.1|
GO terms
2
Lj0g3v0317039.1
– YbaK/aminoacyl-tRNA synthetase-associated domain isoform 1 [Theobroma cacao] gi|508777121|gb|EOY24377.1|
GO terms
1
Lj1g3v0786290.1
– 25.7 kDa protein [Cicer arietinum] gi|7271117|emb|CAB81546.1|
GO terms
1
Lj1g3v0786300.1
–
GO terms
1
Lj1g3v3137930.1
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
GO terms
2
Lj1g3v3918090.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X2 [Cicer arietinum] gi|502147205|ref|XP_004506692.1|
GO terms
2
Lj1g3v3918100.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X2 [Cicer arietinum] gi|502147205|ref|XP_004506692.1|
GO terms
2
Lj2g3v0911740.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502147203|ref|XP_004506691.1|
GO terms
2
Lj3g3v3032100.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502147203|ref|XP_004506691.1|
GO terms
2
Lj3g3v3032100.2
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
GO terms
2
Lj3g3v3032100.3
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
GO terms
2
Lj3g3v3599450.1
– PREDICTED: isoleucine--tRNA ligase, cytoplasmic-like [Cicer arietinum] gi|502144299|ref|XP_004505648.1|
GO terms
2
Lj4g3v0134610.1
– PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1|
GO terms
2
Lj4g3v0134610.2
– PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1|
GO terms
2
Lj4g3v0134610.3
– PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1|
GO terms
2
Lj5g3v2028360.1
– PREDICTED: valyl-tRNA synthetase-like isoform 1 [Glycine max] gi|356535908|ref|XP_003536484.1|
GO terms
2
Lj5g3v2028360.2
– PREDICTED: valyl-tRNA synthetase-like isoform 1 [Glycine max] gi|356535908|ref|XP_003536484.1|
GO terms
2
Lj6g3v0819090.1
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
GO terms
2
Lj6g3v1445620.1
– PREDICTED: isoleucine--tRNA ligase-like [Cicer arietinum] gi|502085158|ref|XP_004487851.1|
GO terms
2
Lj6g3v2006180.1
– PREDICTED: D-tyrosyl-tRNA(Tyr) deacylase-like [Glycine max] gi|356555390|ref|XP_003546015.1|
GO terms
3
LotjaGi1g1v0257700.1
– Prolyl-tRNA synthetase associated domain-containing protein 1; TAIR: AT1G44835.1 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein; Swiss-Prot: sp|A1A4Q2|PRXD1_BOVIN Prolyl-tRNA synthetase associated domain-containing protein 1; TrEMBL-Plants: tr|I1KA79|I1KA79_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0257700
GO terms
1
LotjaGi1g1v0529100.1
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529100
GO terms
2
LotjaGi1g1v0529100.2
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529100
GO terms
2
LotjaGi1g1v0635300_LC.1
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0B2SEG7|A0A0B2SEG7_GLYSO Leucine--tRNA ligase, cytoplasmic; Found in the gene: LotjaGi1g1v0635300_LC
GO terms
2
LotjaGi2g1v0111300.1
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi2g1v0111300.2
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi2g1v0111300.3
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi2g1v0111300.4
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi2g1v0111300.5
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi2g1v0111300.6
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi2g1v0111300.7
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
GO terms
2
LotjaGi3g1v0484200.2
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484200
GO terms
2
LotjaGi3g1v0484200.3
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484200
GO terms
2
LotjaGi3g1v0535700.1
– Isoleucine-tRNA ligase; TAIR: AT4G10320.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|F4JLM5|SYIC_ARATH Isoleucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0S3SEB7|A0A0S3SEB7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0535700
GO terms
2
LotjaGi4g1v0011900.1
– Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JJA8|G7JJA8_MEDTR Leucyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0011900
GO terms
2
LotjaGi4g1v0011900.2
– Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JJA8|G7JJA8_MEDTR Leucyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0011900
GO terms
2
LotjaGi4g1v0011900.3
– Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KNG6|I1KNG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0011900
GO terms
2
LotjaGi4g1v0204800.1
– YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein; TAIR: AT4G16510.1 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein; Swiss-Prot: sp|Q8I1F6|PPO3_DROER Phenoloxidase 3; TrEMBL-Plants: tr|I1K0N8|I1K0N8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0204800
GO terms
1
LotjaGi5g1v0026300.1
– Prolyl-tRNA synthetase associated domain-containing protein 1; TAIR: AT1G44835.2 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein; Swiss-Prot: sp|Q6NRL0|PRXD1_XENLA Prolyl-tRNA synthetase associated domain-containing protein 1; TrEMBL-Plants: tr|I1KA79|I1KA79_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0026300
GO terms
1
LotjaGi5g1v0305000.1
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
GO terms
2
LotjaGi5g1v0305000.2
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
GO terms
2
LotjaGi5g1v0305000.3
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
GO terms
2
LotjaGi5g1v0305000.4
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
GO terms
2
LotjaGi6g1v0153700.1
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700
GO terms
2
LotjaGi6g1v0153700.2
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700
GO terms
2
LotjaGi6g1v0153700.3
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700
GO terms
2
LotjaGi6g1v0249900.1
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
GO terms
2
LotjaGi6g1v0249900.2
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
GO terms
2
LotjaGi6g1v0249900.3
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
GO terms
2
LotjaGi6g1v0249900.4
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
GO terms
2
LotjaGi6g1v0326000.1
– D-aminoacyl-tRNA deacylase; TAIR: AT4G18460.1 D-Tyr-tRNA(Tyr) deacylase family protein; Swiss-Prot: sp|Q54EY1|DTD_DICDI D-tyrosyl-tRNA(Tyr) deacylase; TrEMBL-Plants: tr|A0A0S3S2V1|A0A0S3S2V1_PHAAN D-tyrosyl-tRNA(Tyr) deacylase; Found in the gene: LotjaGi6g1v0326000
GO terms
3
LotjaGi6g1v0326000.2
– D-aminoacyl-tRNA deacylase; TAIR: AT4G18460.1 D-Tyr-tRNA(Tyr) deacylase family protein; Swiss-Prot: sp|Q54EY1|DTD_DICDI D-tyrosyl-tRNA(Tyr) deacylase; TrEMBL-Plants: tr|A0A0L9VFL8|A0A0L9VFL8_PHAAN D-tyrosyl-tRNA(Tyr) deacylase; Found in the gene: LotjaGi6g1v0326000
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0051499
Molecular function D-aminoacyl-tRNA deacylase activity 1 1.79