Gene Ontology — View

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GO:0070176

Overview

Field	Value
Namespace	Cellular component
Short description	DRM complex
Full defintion	A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.
Subterm of	GO:0090571

Relationships

The relationship of GO:0070176 with other GO terms.

Relationship type	GO terms
Is a	GO:0090571
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0070176, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
PMID	Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Harrison MM, Ceol CJ, Lu X, Horvitz HR Proc Natl Acad Sci U S A. 2006 Nov 7; 103 (45): 16782–7.PMID: 17075059 The Caenorhabditis elegans synthetic multivulva (synMuv) genes act redundantly to antagonize the specification of vulval cell fates, which are promoted by an RTK/Ras pathway. At least 26 synMuv genes have been genetically identified, several of which encode proteins with homologs that act in chromatin remodeling or transcriptional repression. Here we report the molecular characterization of two synMuv genes, lin-37 and lin-54. We show that lin-37 and lin-54 encode proteins in a complex with at least seven synMuv proteins, including LIN-35, the only C. elegans homolog of the mammalian tumor suppressor Rb. Biochemical analyses of mutants suggest that LIN-9, LIN-53, and LIN-54 are required for the stable formation of this complex. This complex is distinct from a second complex of synMuv proteins with a composition similar to that of the mammalian Nucleosome Remodeling and Deacetylase complex. The class B synMuv complex we identified is evolutionarily conserved and likely functions in transcriptional repression and developmental regulation.

Field

Value

PMID

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Harrison MM, Ceol CJ, Lu X, Horvitz HR
Proc Natl Acad Sci U S A. 2006 Nov 7; 103 (45): 16782–7.PMID: 17075059

The Caenorhabditis elegans synthetic multivulva (synMuv) genes act redundantly to antagonize the specification of vulval cell fates, which are promoted by an RTK/Ras pathway. At least 26 synMuv genes have been genetically identified, several of which encode proteins with homologs that act in chromatin remodeling or transcriptional repression. Here we report the molecular characterization of two synMuv genes, lin-37 and lin-54. We show that lin-37 and lin-54 encode proteins in a complex with at least seven synMuv proteins, including LIN-35, the only C. elegans homolog of the mammalian tumor suppressor Rb. Biochemical analyses of mutants suggest that LIN-9, LIN-53, and LIN-54 are required for the stable formation of this complex. This complex is distinct from a second complex of synMuv proteins with a composition similar to that of the mammalian Nucleosome Remodeling and Deacetylase complex. The class B synMuv complex we identified is evolutionarily conserved and likely functions in transcriptional repression and developmental regulation.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
Lj1g3v3329960.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Integral membrane protein hemolysin-III like protein [Arabidopsis thaliana] gi\|30689972\|ref\|NP_182050.2\|	GO terms View details of GO:0006351 View details of GO:0070176	2
LotjaGi1g1v0555700.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Integral membrane protein hemolysin-III like protein; TAIR: AT2G45250.1 integral membrane hemolysin-III-like protein; Swiss-Prot: sp\|Q6X4M3\|LIN52_ONCMY Protein lin-52 homolog; TrEMBL-Plants: tr\|I1K6V1\|I1K6V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0555700	GO terms View details of GO:0006351 View details of GO:0070176	2
LotjaGi1g1v0555700.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Integral membrane protein hemolysin-III like protein; TAIR: AT2G45250.1 integral membrane hemolysin-III-like protein; Swiss-Prot: sp\|Q6X4M3\|LIN52_ONCMY Protein lin-52 homolog; TrEMBL-Plants: tr\|I1K6V1\|I1K6V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0555700	GO terms View details of GO:0006351 View details of GO:0070176	2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0070176 View details of GO:0070176 AmiGO InterPro QuickGO	Cellular component	DRM complex	1	33.33