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GO:0071596

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Ubiquitin-dependent protein catabolic process via the N-end rule pathway
Full defintion The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.
Subterm of

Relationships

The relationship of GO:0071596 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCrb
PMID
The N-end rule pathway of protein degradation.Varshavsky A
Genes Cells. 1997 Jan; 2 (1): 13–28.PMID: 9112437

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.

Associated Lotus transcripts 1

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi1g1v0580400.1
– E3 ubiquitin-protein ligase; TAIR: AT5G02310.1 proteolysis 6; Swiss-Prot: sp|F4KCC2|PRT6_ARATH E3 ubiquitin-protein ligase PRT6; TrEMBL-Plants: tr|I1KJZ0|I1KJZ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0580400
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0071596
Biological process Ubiquitin-dependent protein catabolic process via the N-end rule pathway 1 100.00