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Field | Value |
---|---|
Namespace | Molecular function |
Short description | Fatty-acyl-CoA reductase (alcohol-forming) activity |
Full defintion | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
Subterm of |
The relationship of GO:0080019 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0080019, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis. Plant Physiol. 2006 Nov; 142 (3): 866–77.PMID: 16980563 A waxy cuticle that serves as a protective barrier against uncontrolled water loss and environmental damage coats the aerial surfaces of land plants. It is composed of a cutin polymer matrix and waxes. Cuticular waxes are complex mixtures of very-long-chain fatty acids and their derivatives. We report here the molecular cloning and characterization of CER4, a wax biosynthetic gene from Arabidopsis (Arabidopsis thaliana). Arabidopsis cer4 mutants exhibit major decreases in stem primary alcohols and wax esters, and slightly elevated levels of aldehydes, alkanes, secondary alcohols, and ketones. This phenotype suggested that CER4 encoded an alcohol-forming fatty acyl-coenzyme A reductase (FAR). We identified eight FAR-like genes in Arabidopsis that are highly related to an alcohol-forming FAR expressed in seeds of jojoba (Simmondsia chinensis). Molecular characterization of CER4 alleles and genomic complementation revealed that one of these eight genes, At4g33790, encoded the FAR required for cuticular wax production. Expression of CER4 cDNA in yeast (Saccharomyces cerevisiae) resulted in the accumulation of C24:0 and C26:0 primary alcohols. Fully functional green fluorescent protein-tagged CER4 protein was localized to the endoplasmic reticulum in yeast cells by confocal microscopy. Analysis of gene expression by reverse transcription-PCR indicated that CER4 was expressed in leaves, stems, flowers, siliques, and roots. Expression of a beta-glucuronidase reporter gene driven by the CER4 promoter in transgenic plants was detected in epidermal cells of leaves and stems, consistent with a dedicated role for CER4 in cuticular wax biosynthesis. CER4 was also expressed in all cell types in the elongation zone of young roots. These data indicate that CER4 is an alcohol-forming FAR that has specificity for very-long-chain fatty acids and is responsible for the synthesis of primary alcohols in the epidermal cells of aerial tissues and in roots. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: fatty acyl-CoA reductase 3-like [Glycine max] gi|356543580|ref|XP_003540238.1| | 1 | ||
– | Fatty acyl-CoA reductase [Medicago truncatula] gi|357491041|ref|XP_003615808.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 2-like [Glycine max] gi|356503040|ref|XP_003520320.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 3-like [Glycine max] gi|356543578|ref|XP_003540237.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 3-like isoform 1 [Glycine max] gi|356550111|ref|XP_003543433.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 3-like isoform 1 [Glycine max] gi|356542728|ref|XP_003539817.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 3-like [Glycine max] gi|356539286|ref|XP_003538130.1| | 1 | ||
– | Fatty acyl-CoA reductase [Medicago truncatula] gi|357471749|ref|XP_003606159.1| | 1 | ||
– | Fatty acyl-CoA reductase [Medicago truncatula] gi|357471757|ref|XP_003606163.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 3-like [Glycine max] gi|356541416|ref|XP_003539173.1| | 1 | ||
– | Fatty acyl-CoA reductase [Medicago truncatula] gi|357471757|ref|XP_003606163.1| | 1 | ||
– | PREDICTED: fatty acyl-CoA reductase 2-like [Glycine max] gi|356503040|ref|XP_003520320.1| | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A0B2QMM1|A0A0B2QMM1_GLYSO Fatty acyl-CoA reductase; Found in the gene: LotjaGi3g1v0175200 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q9XGY7|FAR_SIMCH Alcohol-forming fatty acyl-CoA reductase; TrEMBL-Plants: tr|K7M318|K7M318_SOYBN Fatty acyl-CoA reductase; Found in the gene: LotjaGi3g1v0175300 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|I1LRE5|I1LRE5_SOYBN Fatty acyl-CoA reductase; Found in the gene: LotjaGi3g1v0478900 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|I3T467|I3T467_LOTJA Fatty acyl-CoA reductase; Found in the gene: LotjaGi3g1v0479000 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A1J7HZ71|A0A1J7HZ71_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0479100 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A1J7HZ71|A0A1J7HZ71_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0479100 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A1J7HZ71|A0A1J7HZ71_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0479100 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A1J7HZ71|A0A1J7HZ71_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0479300 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A1J7HZ71|A0A1J7HZ71_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0479300 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT4G33790.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q93ZB9|FACR3_ARATH Fatty acyl-CoA reductase 3; TrEMBL-Plants: tr|A0A1J7HZ71|A0A1J7HZ71_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0479300 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT5G22500.1 fatty acid reductase 1; Swiss-Prot: sp|Q39152|FACR1_ARATH Fatty acyl-CoA reductase 1; TrEMBL-Plants: tr|A0A0L9V689|A0A0L9V689_PHAAN Fatty acyl-CoA reductase; Found in the gene: LotjaGi4g1v0129900 | 1 | ||
– | Fatty acyl-CoA reductase; TAIR: AT3G11980.1 Jojoba acyl CoA reductase-related male sterility protein; Swiss-Prot: sp|Q08891|FACR2_ARATH Fatty acyl-CoA reductase 2; TrEMBL-Plants: tr|A0A072VJJ5|A0A072VJJ5_MEDTR Fatty acyl-CoA reductase; Found in the gene: LotjaGi5g1v0115200 | 1 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Molecular function | Fatty-acyl-CoA reductase (alcohol-forming) activity | 1 | 4.17 |