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Field | Value |
---|---|
Namespace | Cellular component |
Short description | EARP complex |
Full defintion | A quatrefoil tethering complex required for endocytic recycling. |
Subterm of |
The relationship of GO:1990745 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:1990745, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | EARP is a multisubunit tethering complex involved in endocytic recycling. Nat Cell Biol. 2015 May; 17 (5): 639–50.PMID: 25799061 Recycling of endocytic receptors to the cell surface involves passage through a series of membrane-bound compartments by mechanisms that are poorly understood. In particular, it is unknown if endocytic recycling requires the function of multisubunit tethering complexes, as is the case for other intracellular trafficking pathways. Herein we describe a tethering complex named endosome-associated recycling protein (EARP) that is structurally related to the previously described Golgi-associated retrograde protein (GARP) complex. The two complexes share the Ang2, Vps52 and Vps53 subunits, but EARP contains an uncharacterized protein, syndetin, in place of the Vps54 subunit of GARP. This change determines differential localization of EARP to recycling endosomes and GARP to the Golgi complex. EARP interacts with the target SNARE syntaxin 6 and various cognate SNAREs. Depletion of syndetin or syntaxin 6 delays recycling of internalized transferrin to the cell surface. These findings implicate EARP in canonical membrane-fusion events in the process of endocytic recycling. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Coiled-coil domain-containing protein 132; TAIR: AT2G27900.1 coiled-coil protein; Swiss-Prot: sp|Q5ZKV9|VPS50_CHICK Syndetin; TrEMBL-Plants: tr|I1LRA9|I1LRA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0482400 | 3 | ||
– | Coiled-coil domain-containing protein 132; TAIR: AT2G27900.1 coiled-coil protein; Swiss-Prot: sp|Q5ZKV9|VPS50_CHICK Syndetin; TrEMBL-Plants: tr|I1LRA9|I1LRA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0482400 | 3 | ||
– | Coiled-coil domain-containing protein 132; TAIR: AT2G27900.1 coiled-coil protein; Swiss-Prot: sp|Q5ZKV9|VPS50_CHICK Syndetin; TrEMBL-Plants: tr|I1LRA9|I1LRA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0482400 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | EARP complex | 1 | 33.33 |