Description

IPR000043 is a Adenosylhomocysteinase-like.

<p>Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, [ec:3.3.1.1]) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+ [[cite:PUB00021119], [cite:PUB00038377], [cite:PUB00079516], [cite:PUB00079517]].</p> <p>This family also includes S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), also known as IRBIT, and S-adenosylhomocysteine hydrolase-like protein 2 (Ahcyl2). Ahcyl1/IRBIT was shown to interact with inositol 1,4,5-trisphosphate receptors (IP3Rs), which function as intracellular Ca(2+) channels, and suppresses IP3 binding of IP3R [[cite:PUB00083401], [cite:PUB00083402]]. By competing with IP3, it modulates the threshold IP3 concentration required for the activation of the receptor [[cite:PUB00083401]]. Further studies indicate that Ahcyl1/IRBIT is in fact a multifunctional protein that regulates several ion channels and ion transporters [[cite:PUB00083432], [cite:PUB00083433]]. Despite its homology to S-adenosylhomocysteine hydrolases, Ahcyl1 has neither enzyme activity nor any effects on the enzyme activity of S-adenosylhomocysteine hydrolase [[cite:PUB00083397]]. Ahcyl2 lacks binding activity to IP3R [[cite:PUB00083418]]. Ahcyl2 upregulates NBCe1-B, which plays an important role in intracellular pH regulation [[cite:PUB00083434]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: