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IPR020082 is a S-adenosyl-L-homocysteine hydrolase, conserved site.
<p>Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, [ec:3.3.1.1]) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+ [[cite:PUB00021119], [cite:PUB00038377], [cite:PUB00079516], [cite:PUB00079517]].</p> <p>This entry represents two highly conserved regions. The first pattern is located in the N-terminal section; the second is derived from a glycine-rich region in the central part of S-adenosyl-L-homocysteine hydrolase, a region thought to be involved in NAD-binding.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | S-adenosyl-L-homocysteine hydrolase [Populus tomentosa] gi|429326634|gb|AFZ78657.1| | 14 | ||
| – | Adenosylhomocysteinase; TAIR: AT4G13940.1 S-adenosyl-L-homocysteine hydrolase; Swiss-Prot: sp|O23255|SAHH1_ARATH Adenosylhomocysteinase 1; TrEMBL-Plants: tr|I1KS65|I1KS65_SOYBN Adenosylhomocysteinase; Found in the gene: LotjaGi4g1v0371500 | 21 | ||
| – | Adenosylhomocysteinase; TAIR: AT4G13940.1 S-adenosyl-L-homocysteine hydrolase; Swiss-Prot: sp|O23255|SAHH1_ARATH Adenosylhomocysteinase 1; TrEMBL-Plants: tr|I1KS65|I1KS65_SOYBN Adenosylhomocysteinase; Found in the gene: LotjaGi4g1v0371500 | 19 | ||
| – | Adenosylhomocysteinase; TAIR: AT4G13940.3 S-adenosyl-L-homocysteine hydrolase; Swiss-Prot: sp|O23255|SAHH1_ARATH Adenosylhomocysteinase 1; TrEMBL-Plants: tr|F4JTV4|F4JTV4_ARATH Adenosylhomocysteinase; Found in the gene: LotjaGi4g1v0371500 | 20 | ||
| – | Adenosylhomocysteinase; TAIR: AT4G13940.1 S-adenosyl-L-homocysteine hydrolase; Swiss-Prot: sp|O23255|SAHH1_ARATH Adenosylhomocysteinase 1; TrEMBL-Plants: tr|I1KS65|I1KS65_SOYBN Adenosylhomocysteinase; Found in the gene: LotjaGi4g1v0371500 | 21 | ||
| – | Adenosylhomocysteinase; TAIR: AT3G23810.1 S-adenosyl-l-homocysteine (SAH) hydrolase 2; Swiss-Prot: sp|P35007|SAHH_CATRO Adenosylhomocysteinase; TrEMBL-Plants: tr|A0A061ELA5|A0A061ELA5_THECC Adenosylhomocysteinase; Found in the gene: LotjaGi6g1v0040900 | 21 | ||
| – | Adenosylhomocysteinase; TAIR: AT3G23810.1 S-adenosyl-l-homocysteine (SAH) hydrolase 2; Swiss-Prot: sp|Q01781|SAHH_PETCR Adenosylhomocysteinase; TrEMBL-Plants: tr|A0A061ELA5|A0A061ELA5_THECC Adenosylhomocysteinase; Found in the gene: LotjaGi6g1v0040900 | 19 | ||
| – | Adenosylhomocysteinase; TAIR: AT4G13940.3 S-adenosyl-L-homocysteine hydrolase; Swiss-Prot: sp|P35007|SAHH_CATRO Adenosylhomocysteinase; TrEMBL-Plants: tr|F4JTV4|F4JTV4_ARATH Adenosylhomocysteinase; Found in the gene: LotjaGi6g1v0040900 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00401 | CDD | 1 | 12.50 |