Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR000111 is a Glycoside hydrolase family 27/36, conserved site.
<p>O-Glycosyl hydrolases ([ec:3.2.1]) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PUB00004870], [cite:PUB00005266]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Families 27 ([cazy:GH27]) and 36 ([cazy:GH36]) encompasses alpha-galactosidases and alpha-N-acetylgalactosaminidases.</p> <p>Alpha-galactosidase ([ec:3.2.1.22]) (melibiase) [[cite:PUB00000002]] catalyses the hydrolysis of melibiose into galactose and glucose. In man, the deficiency of this enzyme is the cause of Fabry's disease (X-linked sphingolipidosis). Alpha-galactosidase is present in a variety of organisms. There is a considerable degree of similarity in the sequence of alpha-galactosidase from various eukaryotic species. Escherichia coli alpha-galactosidase (gene melA), which requires NAD and magnesium as cofactors, is not structurally related to the eukaryotic enzymes; by contrast, an Escherichia coli plasmid encoded alpha-galactosidase (gene rafA) [[cite:PUB00002094]] contains a region of about 50 amino acids which is similar to a domain of the eukaryotic alpha-galactosidases.</p> <p>Alpha-N-acetylgalactosaminidase ([ec:3.2.1.49]) [[cite:PUB00002595]] catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. In man, the deficiency of this enzyme is the cause of Schindler and Kanzaki diseases. The sequence of this enzyme is highly related to that of the eukaryotic alpha-galactosidases.</p> <p>This entry represents a conserved site in families 27 and 36. It contains two conserved aspartic acid residues which could be involved in the catalytic mechanism.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Hydrolase activity, hydrolyzing O-glycosyl compounds | Catalysis of the hydrolysis of any O-glycosyl bond. | ||
| Biological process | Carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: alpha-galactosidase-like isoform 1 [Glycine max] gi|356516253|ref|XP_003526810.1| | 24 | ||
| – | Alpha-galactosidase; TAIR: AT3G56310.1 Melibiase family protein; Swiss-Prot: sp|Q8VXZ7|AGAL3_ARATH Alpha-galactosidase 3; TrEMBL-Plants: tr|I1KB92|I1KB92_SOYBN Alpha-galactosidase; Found in the gene: LotjaGi1g1v0308200 | 25 | ||
| – | Alpha-galactosidase; TAIR: AT3G56310.1 Melibiase family protein; Swiss-Prot: sp|Q8VXZ7|AGAL3_ARATH Alpha-galactosidase 3; TrEMBL-Plants: tr|I1KB92|I1KB92_SOYBN Alpha-galactosidase; Found in the gene: LotjaGi1g1v0308200 | 25 | ||
| – | Alpha-galactosidase; TAIR: AT5G08380.1 alpha-galactosidase 1; Swiss-Prot: sp|Q9FT97|AGAL1_ARATH Alpha-galactosidase 1; TrEMBL-Plants: tr|A0A072U1H6|A0A072U1H6_MEDTR Alpha-galactosidase; Found in the gene: LotjaGi1g1v0458400 | 25 | ||
| – | Alpha-galactosidase; TAIR: AT5G08370.1 alpha-galactosidase 2; Swiss-Prot: sp|P14749|AGAL_CYATE Alpha-galactosidase; TrEMBL-Plants: tr|V7C549|V7C549_PHAVU Alpha-galactosidase; Found in the gene: LotjaGi2g1v0170000 | 22 | ||
| – | Alpha-galactosidase; TAIR: AT5G08370.1 alpha-galactosidase 2; Swiss-Prot: sp|P14749|AGAL_CYATE Alpha-galactosidase; TrEMBL-Plants: tr|I1LBZ8|I1LBZ8_SOYBN Alpha-galactosidase; Found in the gene: LotjaGi5g1v0053000 | 25 | ||
| – | Alpha-galactosidase; TAIR: AT5G08370.1 alpha-galactosidase 2; Swiss-Prot: sp|P14749|AGAL_CYATE Alpha-galactosidase; TrEMBL-Plants: tr|K7N4X3|K7N4X3_SOYBN Alpha-galactosidase; Found in the gene: LotjaGi5g1v0198300 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd14792 | CDD | 1 | 14.29 |