Description

IPR002241 is a Glycoside hydrolase, family 27.

<p>O-Glycosyl hydrolases ([ec:3.2.1.]) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PUB00004870], [cite:PUB00005266]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.</p> <p>Glycoside hydrolase family 27 [cazy:GH27] comprises enzymes with several known activities; alpha-galactosidase ([ec:3.2.1.22]); alpha-N-acetylgalactosaminidase ([ec:3.2.1.49]); isomalto-dextranase ([ec:3.2.1.94]).</p> <p>Alpha-galactosidase (melibiase) catalyses the hydrolysis of melibiose into galactose and glucose [[cite:PUB00005652]]. In man, deficiency in the enzyme results in Fabry's disease (X-linked sphingolipidosis). Alpha-N-acetylgalactosaminidase catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides [[cite:PUB00002595]]. Two conserved Asp residues may be involved in the catalytic mechanism in these enzymes. Deficiency in this enzyme results in Schindler and Kanzaki diseases.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 25

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: