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IPR000185

Source: InterPro

Description

IPR000185 is a Protein translocase subunit SecA.

<p>Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [[cite:PUB00007064]]. From there, the mature proteins are either targeted to the outer membrane, or remain as periplasmic proteins. The translocase protein subunits are encoded on the bacterial chromosome.</p> <p>The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF) [[cite:PUB00007064]]. The chaperone protein SecB [[cite:PUB00007065]] is a highly acidic homotetrameric protein that exists as a "dimer of dimers" in the bacterial cytoplasm. SecB maintains preproteins in an unfolded state after translation, and targets these to the peripheral membrane protein ATPase SecA for secretion [[cite:PUB00007066]].</p> <p>SecA is a cytoplasmic protein of 800 to 960 amino acid residues. Homologues of secA are also encoded in the chloroplast genome of some algae [[cite:PUB00003757]] as well as in the nuclear genome of plants [[cite:PUB00001687]]. It could be involved in the intraorganellar protein transport into thylakoids.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0006605
Biological process Protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
Subterm of
GO:0006886
Biological process Intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
Subterm of
Part of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0312149.1
– PREDICTED: protein translocase subunit SecA, chloroplastic-like isoform X3 [Cicer arietinum] gi|502117549|ref|XP_004495859.1|
Domains
19
Lj5g3v0321370.1
– PREDICTED: protein translocase subunit SECA2, chloroplastic-like [Cicer arietinum] gi|502136002|ref|XP_004502527.1|
Domains
24
Lj5g3v0321370.2
– PREDICTED: protein translocase subunit SECA2, chloroplastic-like [Cicer arietinum] gi|502136002|ref|XP_004502527.1|
Domains
24
LotjaGi1g1v0265900.1
– Protein translocase subunit SecA; TAIR: AT1G21650.2 Preprotein translocase SecA family protein; Swiss-Prot: sp|D8WUA4|SECA2_ARATH Protein translocase subunit SECA2, chloroplastic; TrEMBL-Plants: tr|K7KUK2|K7KUK2_SOYBN Protein translocase subunit SecA; Found in the gene: LotjaGi1g1v0265900
Domains
28
LotjaGi5g1v0238000.1
– Protein translocase subunit SecA; TAIR: AT4G01800.1 Albino or Glassy Yellow 1; Swiss-Prot: sp|Q41062|SECA_PEA Protein translocase subunit SecA, chloroplastic; TrEMBL-Plants: tr|G7IBQ7|G7IBQ7_MEDTR Protein translocase subunit SecA; Found in the gene: LotjaGi5g1v0238000
Domains
9
LotjaGi5g1v0238000.2
– Protein translocase subunit SecA; TAIR: AT4G01800.1 Albino or Glassy Yellow 1; Swiss-Prot: sp|Q41062|SECA_PEA Protein translocase subunit SecA, chloroplastic; TrEMBL-Plants: tr|G7IBQ7|G7IBQ7_MEDTR Protein translocase subunit SecA; Found in the gene: LotjaGi5g1v0238000
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67