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IPR000771 is a Fructose-bisphosphate aldolase, class-II.
<p>Class-II aldolases [[cite:PUB00005383]], mainly found in prokaryotes and fungi, are homodimeric enzymes, which require a divalent metal ion, generally zinc, for their activity. They include fructose-bisphosphate aldolase [[cite:PUB00000567], [cite:PUB00005383]], a glycolytic enzyme that catalyses the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. The family also includes the Escherichia coli galactitol operon protein, gatY, which catalyses the transformation of tagatose 1,6-bisphosphate into glycerone phosphate and D-glyceraldehyde 3-phosphate; and E. coli N-acetyl galactosamine operon protein, agaY, which catalyses the same reaction. There are two histidine residues in the first half of the sequence of these enzymes that have been shown to be involved in binding a zinc ion [[cite:PUB00001651]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. | ||
| Molecular function | Aldehyde-lyase activity | Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ketose-bisphosphate aldolase class-II family protein isoform 1 [Theobroma cacao] gi|508774096|gb|EOY21352.1| | 32 | ||
| – | D-tagatose-1,6-bisphosphate aldolase subunit gatY [Medicago truncatula] gi|357499101|ref|XP_003619839.1| | 11 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00947 | CDD | 1 | 10.00 |