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IPR029154 is a 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain.
<p>3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. This entry represents the NAD-binding domain of 3-hydroxyisobutyrate dehydrogenase related sequences, such as 6-phosphogluconate dehydrogenase, that adopts a Rossmann fold [[cite:PUB00038120]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | NAD binding | Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial-like [Fragaria vesca subsp]. vesca] gi|470127985|ref|XP_004299936.1| | 15 | ||
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial-like [Fragaria vesca subsp]. vesca] gi|470127985|ref|XP_004299936.1| | 8 | ||
| – | Ketose-bisphosphate aldolase class-II family protein isoform 1 [Theobroma cacao] gi|508774096|gb|EOY21352.1| | 32 | ||
| – | Ketose-bisphosphate aldolase class-II family protein isoform 2 [Theobroma cacao] gi|508774097|gb|EOY21353.1| | 23 | ||
| – | Hydroxyacid dehydrogenase/reductase; 6-phosphogluconate dehydrogenase, C-terminal-like [Medicago truncatula] gi|124359345|gb|ABD28508.2| | 15 | ||
| – | PREDICTED: glyoxylate/succinic semialdehyde reductase 1-like [Cicer arietinum] gi|502157000|ref|XP_004510724.1| | 13 | ||
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial-like [Cicer arietinum] gi|502138668|ref|XP_004503489.1| | 15 | ||
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial-like isoform X1 [Cicer arietinum] gi|502080130|ref|XP_004486468.1| | 19 | ||
| – | PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial-like isoform X1 [Cicer arietinum] gi|502080130|ref|XP_004486468.1| | 9 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100 | 31 | ||
| – | 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT1G17650.1 glyoxylate reductase 2; Swiss-Prot: sp|F4I907|GLYR2_ARATH Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; TrEMBL-Plants: tr|G7IUG9|G7IUG9_MEDTR Glyoxylate/succinic semialdehyde reductase; Found in the gene: LotjaGi3g1v0026900 | 15 | ||
| – | 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT1G17650.1 glyoxylate reductase 2; Swiss-Prot: sp|F4I907|GLYR2_ARATH Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; TrEMBL-Plants: tr|G7IUG9|G7IUG9_MEDTR Glyoxylate/succinic semialdehyde reductase; Found in the gene: LotjaGi3g1v0026900 | 15 | ||
| – | 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT3G25530.1 glyoxylate reductase 1; Swiss-Prot: sp|Q9LSV0|GLYR1_ARATH Glyoxylate/succinic semialdehyde reductase 1; TrEMBL-Plants: tr|A0A1J7GPF6|A0A1J7GPF6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391100 | 17 | ||
| – | 6-phosphogluconate dehydrogenase family protein; TAIR: AT4G29120.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SZE1|3HID1_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial; TrEMBL-Plants: tr|A0A072TUY6|A0A072TUY6_MEDTR 6-phosphogluconate dehydrogenase NAD-binding domain protein; Found in the gene: LotjaGi4g1v0445200 | 13 | ||
| – | 6-phosphogluconate dehydrogenase family protein; TAIR: AT4G29120.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SZE1|3HID1_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial; TrEMBL-Plants: tr|I1K5Z3|I1K5Z3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0445200 | 15 | ||
| – | 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100 | 18 | ||
| – | 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100 | 17 | ||
| – | 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100 | 17 | ||
| – | 6-phosphogluconate dehydrogenase-like protein; TAIR: AT1G71180.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q949M8|3HID3_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial; TrEMBL-Plants: tr|W9QFQ0|W9QFQ0_9ROSA Putative oxidoreductase ykwC; Found in the gene: LotjaGi6g1v0360300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51735 | SUPERFAMILY | 1 | 3.85 |