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IPR000806 is a Rab GDI protein.
<p>Rab proteins, a family of small Ras-related GTP-binding proteins, are involved in regulation of intracellular vesicle trafficking [[cite:PUB00000785]]. Rab GDP dissociation inhibitor (GDI) forms a soluble complex with Rab proteins, thereby preventing exchange of GDP for GTP. Rab GDI exists in several isoforms, and belongs to the TCD/MRS6 family of GDP dissociation inhibitors. <p>The crystal structure of the bovine alpha-isoform of Rab GDI has been determined to a resolution of 1.81A [[cite:PUB00004235]]. The protein is composed of two main structural units: a large complex multi-sheet domain I, and a smaller α-helical domain II.</p> <p>The structural organisation of domain I is closely related to FAD-containing monooxygenases and oxidases [[cite:PUB00004235]]. Conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the domain [[cite:PUB00000785]]. The two most conserved regions form a compact structure at the apex of the molecule; site-directed mutagenesis has shown these regions to play a critical role in the binding of Rab proteins [[cite:PUB00004235]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. | ||
| Biological process | Protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: rab GDP dissociation inhibitor alpha-like [Glycine max] gi|356521229|ref|XP_003529259.1| | 12 | ||
| – | PREDICTED: rab GDP dissociation inhibitor alpha-like [Cicer arietinum] gi|502140390|ref|XP_004504200.1| | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT5G09550.1 GDP dissociation inhibitor family protein / Rab GTPase activator family protein; Swiss-Prot: sp|Q9LXC0|GDI_ARATH Guanosine nucleotide diphosphate dissociation inhibitor At5g09550; TrEMBL-Plants: tr|A0A151T282|A0A151T282_CAJCA Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0039100 | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT5G09550.1 GDP dissociation inhibitor family protein / Rab GTPase activator family protein; Swiss-Prot: sp|Q9LXC0|GDI_ARATH Guanosine nucleotide diphosphate dissociation inhibitor At5g09550; TrEMBL-Plants: tr|A0A151T282|A0A151T282_CAJCA Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0039100 | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT2G44100.1 guanosine nucleotide diphosphate dissociation inhibitor 1; Swiss-Prot: sp|Q96254|GDI1_ARATH Guanosine nucleotide diphosphate dissociation inhibitor 1; TrEMBL-Plants: tr|O65744|O65744_CICAR Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0387400 | 13 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT2G44100.1 guanosine nucleotide diphosphate dissociation inhibitor 1; Swiss-Prot: sp|Q96254|GDI1_ARATH Guanosine nucleotide diphosphate dissociation inhibitor 1; TrEMBL-Plants: tr|O65744|O65744_CICAR Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0387400 | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT2G44100.1 guanosine nucleotide diphosphate dissociation inhibitor 1; Swiss-Prot: sp|Q96254|GDI1_ARATH Guanosine nucleotide diphosphate dissociation inhibitor 1; TrEMBL-Plants: tr|O65744|O65744_CICAR Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0387400 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54373 | SUPERFAMILY | 1 | 14.29 |