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IPR018203 is a GDP dissociation inhibitor.
<p>Rab proteins constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic [[cite:PUB00001266], [cite:PUB00000785]]; C-terminal geranylgeranylation is crucial for their membrane association and function. This post-translational modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit enzyme that contains a catalytic heterodimer and an accessory component, termed Rab escort protein (REP)-1 [[cite:PUB00001266]]. REP-1 presents newly- synthesised Rab proteins to the catalytic component, and forms a stable complex with the prenylated proteins following the transfer reaction. <p>The mechanism of REP-1-mediated membrane association of Rab5 is similar to that mediated by Rab GDP dissociation inhibitor (GDI). REP-1 and Rab GDI also share other functional properties, including the ability to inhibit the release of GDP and to remove Rab proteins from membranes.</p> <p>The crystal structure of the bovine alpha-isoform of Rab GDI has been determined to a resolution of 1.81A [[cite:PUB00004235]]. The protein is composed of two main structural units: a large complex multi-sheet domain I, and a smaller α-helical domain II.</p> <p>The structural organisation of domain I is closely related to FAD-containing monooxygenases and oxidases [[cite:PUB00004235]]. Conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the domain [[cite:PUB00000785]]. The two most conserved regions form a compact structure at the apex of the molecule; site-directed mutagenesis has shown these regions to play a critical role in the binding of Rab proteins [[cite:PUB00004235]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. | ||
| Biological process | Small GTPase mediated signal transduction | Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: rab proteins geranylgeranyltransferase component A-like [Glycine max] gi|356496561|ref|XP_003517135.1| | 9 | ||
| – | PREDICTED: rab proteins geranylgeranyltransferase component A 2-like [Cicer arietinum] gi|502161729|ref|XP_004512265.1| | 11 | ||
| – | PREDICTED: rab GDP dissociation inhibitor alpha-like [Glycine max] gi|356521229|ref|XP_003529259.1| | 12 | ||
| – | PREDICTED: rab GDP dissociation inhibitor alpha-like [Cicer arietinum] gi|502140390|ref|XP_004504200.1| | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT3G06540.1 Rab escort protein; Swiss-Prot: sp|Q8LLD4|REP_ARATH Rab escort protein 1; TrEMBL-Plants: tr|I1J8C9|I1J8C9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0355200 | 14 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT5G09550.1 GDP dissociation inhibitor family protein / Rab GTPase activator family protein; Swiss-Prot: sp|Q9LXC0|GDI_ARATH Guanosine nucleotide diphosphate dissociation inhibitor At5g09550; TrEMBL-Plants: tr|A0A151T282|A0A151T282_CAJCA Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0039100 | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT5G09550.1 GDP dissociation inhibitor family protein / Rab GTPase activator family protein; Swiss-Prot: sp|Q9LXC0|GDI_ARATH Guanosine nucleotide diphosphate dissociation inhibitor At5g09550; TrEMBL-Plants: tr|A0A151T282|A0A151T282_CAJCA Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0039100 | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT2G44100.1 guanosine nucleotide diphosphate dissociation inhibitor 1; Swiss-Prot: sp|Q96254|GDI1_ARATH Guanosine nucleotide diphosphate dissociation inhibitor 1; TrEMBL-Plants: tr|O65744|O65744_CICAR Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0387400 | 13 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT2G44100.1 guanosine nucleotide diphosphate dissociation inhibitor 1; Swiss-Prot: sp|Q96254|GDI1_ARATH Guanosine nucleotide diphosphate dissociation inhibitor 1; TrEMBL-Plants: tr|O65744|O65744_CICAR Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0387400 | 12 | ||
| – | Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT2G44100.1 guanosine nucleotide diphosphate dissociation inhibitor 1; Swiss-Prot: sp|Q96254|GDI1_ARATH Guanosine nucleotide diphosphate dissociation inhibitor 1; TrEMBL-Plants: tr|O65744|O65744_CICAR Guanosine nucleotide diphosphate dissociation inhibitor; Found in the gene: LotjaGi4g1v0387400 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54373 | SUPERFAMILY | 1 | 10.00 |