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IPR000926

Source: InterPro

Description

IPR000926 is a GTP cyclohydrolase II, RibA.

<p>GTP cyclohydrolase II (also known as ribA) catalyses the first committed step in the biosynthesis of riboflavin (vitamin b2). The enzyme converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate (APy), formate and pyrophosphate, and requires magnesium as a cofactor. In numerous bacteria and in plants, GTP cyclohydrolase II occurs in the C-terminal of a bifunctional enzyme known as ribBA, which also comprises an N-terminal 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP_synthase, also known as RibB) ([interpro:IPR000422]). RibB catalyses the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [[cite:PUB00076431]].</p> <p>A paralogous protein is encoded in the genome of Streptomyces coelicolor, which converts GTP to 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (FAPy), an activity that has otherwise been reported for unrelated GTP cyclohydrolases III [[cite:PUB00080016]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003935
Molecular function GTP cyclohydrolase II activity Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+).
Subterm of
GO:0009231
Biological process Riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0354109.1
– PREDICTED: riboflavin biosynthesis protein ribBA, chloroplastic-like [Glycine max] gi|356558318|ref|XP_003547454.1|
Domains
17
Lj6g3v2203730.1
– PREDICTED: riboflavin biosynthesis protein ribBA, chloroplastic-like [Glycine max] gi|356554732|ref|XP_003545697.1|
Domains
19
LotjaGi3g1v0279800.1
– GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; TAIR: AT5G59750.1 monofunctional riboflavin biosynthesis protein RIBA 3; Swiss-Prot: sp|Q9FN89|RIBA3_ARATH Monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic; TrEMBL-Plants: tr|K7M9H6|K7M9H6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0279800
Domains
19
LotjaGi3g1v0279800.2
– GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; TAIR: AT5G59750.1 monofunctional riboflavin biosynthesis protein RIBA 3; Swiss-Prot: sp|Q9FN89|RIBA3_ARATH Monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic; TrEMBL-Plants: tr|K7M9H6|K7M9H6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0279800
Domains
19
LotjaGi4g1v0038000.1
– 3,4-dihydroxy-2-butanone 4-phosphate synthase; TAIR: AT5G64300.1 GTP cyclohydrolase II; Swiss-Prot: sp|P47924|RIBA1_ARATH Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic; TrEMBL-Plants: tr|A0A1J7I8M0|A0A1J7I8M0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0038000
Domains
21
LotjaGi6g1v0350800.1
– 3,4-dihydroxy-2-butanone 4-phosphate synthase; TAIR: AT5G64300.1 GTP cyclohydrolase II; Swiss-Prot: sp|P47924|RIBA1_ARATH Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic; TrEMBL-Plants: tr|I1MDY7|I1MDY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0350800
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67