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IPR001018 is a Beta-lactamase, class-B, conserved site.
<p>Synonym(s): Penicillinase, Cephalosporinase <p>Beta-lactamases ([ec:3.5.2.6]) are enzymes which catalyse the hydrolysis of an amide bond in the beta-lactam ring of antibiotics belonging to the penicillin/cephalosporin family. The class B enzymes are zinc containing proteins whilst class A, C and D enzymes are serine hydrolases. Class B beta-lactamases have been described in several Gram-negative bacterial species; they seem to share the characteristic of being able to hydrolyse carbapenem compounds, new beta-lactam antibiotics of great therapeutic potential.</p> <p>The conserved regions in the sequence of known class B beta-lactamases are centred on residues known to be involved in binding the zinc ion essential for the enzymes catalytic activity [[cite:PUB00000136], [cite:PUB00005282]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. | ||
| Molecular function | Beta-lactamase activity | Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. | ||
| Biological process | Antibiotic catabolic process | The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable hydroxyacylglutathione hydrolase 2, chloroplast-like [Glycine max] gi|356545443|ref|XP_003541152.1| | 15 | ||
| – | PREDICTED: probable hydroxyacylglutathione hydrolase 2, chloroplast-like [Glycine max] gi|356545443|ref|XP_003541152.1| | 9 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I3SKI5|I3SKI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500500 | 18 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I3SKI5|I3SKI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500500 | 18 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I3SKI5|I3SKI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500500 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07723 | CDD | 1 | 20.00 |