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IPR035680 is a Hydroxyacylglutathione hydrolase, MBL domain.
<p>Hydroxyacylglutathione hydrolase is also known as glyoxalase II, S-2-hydroxylacylglutathione hydrolase, hydroxyacylglutathione hydrolase, or acetoacetylglutathione hydrolase. In the second step of the glyoxalase system this enzyme hydrolyzes S-d-lactoylglutathione to d-lactate and regenerates glutathione in the process. It has broad substrate specificity for glutathione thiol esters, hydrolyzing a number of these species to their corresponding carboxylic acids and reduced glutathione [[cite:PUB00085866], [cite:PUB00030264]].</p> <p>Glyoxalase II belongs to the metallo-beta-lactamase (MBL)-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions [[cite:PUB00085867]]. The enzyme consists of two domains. The first domain folds into a four-layered β sandwich, similar to that seen in the metallo-beta-lactamases. The second domain is predominantly α-helical. The active site contains a binuclear zinc-binding site and a substrate-binding site extending over the domain interface [[cite:PUB00030264]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Hydroxyacylglutathione hydrolase; TAIR: AT3G10850.1 Metallo-hydrolase/oxidoreductase superfamily protein; Swiss-Prot: sp|O24496|GLO2C_ARATH Hydroxyacylglutathione hydrolase cytoplasmic; TrEMBL-Plants: tr|I3SRG4|I3SRG4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0129000 | 15 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.2 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|C6TKG9|C6TKG9_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0032100 | 15 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I1MD49|I1MD49_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032100 | 16 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I1MD49|I1MD49_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032100 | 16 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I1M574|I1M574_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032100 | 16 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I3SKI5|I3SKI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500500 | 18 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I3SKI5|I3SKI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500500 | 18 | ||
| – | Hydroxyacylglutathione hydrolase; TAIR: AT1G06130.1 glyoxalase 2-4; Swiss-Prot: sp|Q8LDW8|GLO2D_ARATH Probable hydroxyacylglutathione hydrolase 2, chloroplastic; TrEMBL-Plants: tr|I3SKI5|I3SKI5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500500 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07723 | CDD | 1 | 12.50 |