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IPR001249 is a Acetyl-CoA biotin carboxyl carrier.
<p>The proteins in this family are a component of the acetyl coenzyme A carboxylase complex ([ec:6.4.1.2]) and are involved in the first step in long-chain fatty acid synthesis. In plants this is usually located in the chloroplast. In the first step, biotin carboxylase catalyses the carboxylation of the carrier protein to form an intermediate. Next, the transcarboxylase complex transfers the carboxyl group from the intermediate to acetyl-CoA forming malonyl-CoA. This protein functions in the transfer of CO<sub>2</sub>from one site to another, the biotin binding site locates to the C-terminal of this protein. The biotin is specifically attached to a lysine residue in the sequence AMKM.</p> <p>The structure of the C-terminal domain of the biotin carboxyl carrier (BCC) protein was shown to be a flattened β-barrel structure comprising two four-stranded β sheets interrupted by a structural loop forming a thumb structure. The biotinyl-lysine is located on a tight β-turn on the opposite end of the molecule. The thumb structure has been shown to attached biotin, thus stabilising the structure.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Acetyl-CoA carboxylase activity | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. | ||
| Biological process | Fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | ||
| Cellular component | Acetyl-CoA carboxylase complex | A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic-like [Glycine max] gi|356531878|ref|XP_003534503.1| | 16 | ||
| – | Biotin carboxyl carrier protein subunit [Glycine max] gi|351721795|ref|NP_001235174.1| | 15 | ||
| – | PREDICTED: biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic-like [Glycine max] gi|356551156|ref|XP_003543944.1| | 15 | ||
| – | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; TAIR: AT5G16390.1 chloroplastic acetylcoenzyme A carboxylase 1; Swiss-Prot: sp|Q42783|BCCP_SOYBN Biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic; TrEMBL-Plants: tr|I3RZK7|I3RZK7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0486900 | 16 | ||
| – | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; TAIR: AT5G15530.1 biotin carboxyl carrier protein 2; Swiss-Prot: sp|Q9LLC1|BCCP2_ARATH Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic; TrEMBL-Plants: tr|I3SZG2|I3SZG2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0510100 | 15 | ||
| – | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; TAIR: AT5G15530.1 biotin carboxyl carrier protein 2; Swiss-Prot: sp|Q9LLC1|BCCP2_ARATH Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic; TrEMBL-Plants: tr|I3SWG0|I3SWG0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0265400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |