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IPR001250

Source: InterPro

Description

IPR001250 is a Mannose-6-phosphate isomerase, type I.

<p>Mannose-6-phosphate isomerase or phosphomannose isomerase ([ec:5.3.1.8]) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N-and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals [[cite:PUB00007419]]. Three classes of PMI have been defined [[cite:PUB00001448]].</p> <p>Type I includes eukaryotic PMI and the enzyme encoded by the manA gene in enterobacteria. PMI has a bound zinc ion, which is essential for activity.</p> <p>A crystal structure of PMI from<i>Candida albicans</i>shows that the enzyme has three distinct domains [[cite:PUB00003929]]. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004476
Molecular function Mannose-6-phosphate isomerase activity Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
Subterm of
GO:0005975
Biological process Carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
Subterm of
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0344639.1
– Phosphomannose isomerase [Cyamopsis tetragonoloba] gi|60617303|gb|AAX31279.1|
Domains
13
Lj1g3v3313150.1
– PREDICTED: mannose-6-phosphate isomerase-like [Glycine max] gi|356527492|ref|XP_003532343.1|
Domains
9
LotjaGi1g1v0549400.1
– Mannose-6-phosphate isomerase; TAIR: AT3G02570.1 Mannose-6-phosphate isomerase, type I; Swiss-Prot: sp|Q9M884|MPI1_ARATH Mannose-6-phosphate isomerase 1; TrEMBL-Plants: tr|Q5BMC5|Q5BMC5_CYATE Phosphomannose isomerase; Found in the gene: LotjaGi1g1v0549400
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00218 TIGRFAM 1 33.33