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IPR016305 is a Mannose-6-phosphate isomerase.
<p>Mannose-6-phosphate isomerase or phosphomannose isomerase ([ec:5.3.1.8]) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N-and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals [[cite:PUB00007419]]. Three classes of PMI have been defined [[cite:PUB00001448]].</p> <p>This group represents a mannose-6-phosphate isomerase.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. | ||
Biological process | GDP-mannose biosynthetic process | The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Phosphomannose isomerase [Cyamopsis tetragonoloba] gi|60617303|gb|AAX31279.1| | 13 | ||
– | PREDICTED: mannose-6-phosphate isomerase-like [Glycine max] gi|356527492|ref|XP_003532343.1| | 9 | ||
– | Mannose-6-phosphate isomerase; TAIR: AT3G02570.1 Mannose-6-phosphate isomerase, type I; Swiss-Prot: sp|Q9M884|MPI1_ARATH Mannose-6-phosphate isomerase 1; TrEMBL-Plants: tr|Q5BMC5|Q5BMC5_CYATE Phosphomannose isomerase; Found in the gene: LotjaGi1g1v0549400 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
TIGR00218 | TIGRFAM | 1 | 33.33 |