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IPR001308 is a Electron transfer flavoprotein alpha subunit/FixB.
<p>This entry includes electron transfer flavoprotein alpha subunit and the FixB protein.</p> <p>Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II) [[cite:PUB00033231]].</p> <p>ETFs are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP [[cite:PUB00004936], [cite:PUB00005086], [cite:PUB00004879], [cite:PUB00024527], [cite:PUB00033232]]. ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit. Domains I and III share an almost identical α-β-α sandwich fold, while domain II forms an α-β-α sandwich similar to that of bacterial flavodoxins. FAD is bound in a cleft between domains II and III, while domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein, forming a shallow bowl where domain II resides. The alpha subunit of both Group I and Group II ETFs is composed of domains I and II.</p> <p>Many enterobacteria are able to convert carnitine, via crotonobetaine, to gamma-butyrobetaine in the presence of carbon and nitrogen sources under anaerobic conditions [[cite:PUB00053911]]. In Escherichia coli the enzymes involved in this pathway are encoded by the caiTABCDE operon [[cite:PUB00003866]]. The adjacent but divergent fixABCD operon also appears to be necessary for carnintine meatbolism [[cite:PUB00054253]]. The Fix proteins are homologous to proteins found in known electron transport pathways.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Electron transfer activity | Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: electron transfer flavoprotein subunit alpha, mitochondrial-like [Cicer arietinum] gi|502143739|ref|XP_004505448.1| | 19 | ||
| – | Electron transfer flavoprotein subunit alpha, mitochondrial; TAIR: AT1G50940.1 electron transfer flavoprotein alpha; Swiss-Prot: sp|Q9C6I6|ETFA_ARATH Electron transfer flavoprotein subunit alpha, mitochondrial; TrEMBL-Plants: tr|I3SFR5|I3SFR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148500 | 19 | ||
| – | Electron transfer flavoprotein subunit alpha; TAIR: AT1G50940.1 electron transfer flavoprotein alpha; Swiss-Prot: sp|Q9C6I6|ETFA_ARATH Electron transfer flavoprotein subunit alpha, mitochondrial; TrEMBL-Plants: tr|I3SFR5|I3SFR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148500 | 24 | ||
| – | Electron transfer flavoprotein subunit alpha; TAIR: AT1G50940.1 electron transfer flavoprotein alpha; Swiss-Prot: sp|Q9C6I6|ETFA_ARATH Electron transfer flavoprotein subunit alpha, mitochondrial; TrEMBL-Plants: tr|I3SFR5|I3SFR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148500 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01715 | CDD | 1 | 25.00 |