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IPR014730 is a Electron transfer flavoprotein, alpha/beta-subunit, N-terminal.
<p>This entry represents the N-terminal domain of both the alpha and beta subunits from Group I and Group II ETFs.</p> <p>Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II) [[cite:PUB00033231]].</p> <p>ETFs are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP [[cite:PUB00004936], [cite:PUB00005086], [cite:PUB00004879], [cite:PUB00024527], [cite:PUB00033232]]. ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit. Domains I and III share an almost identical α-β-α sandwich fold, while domain II forms an α-β-α sandwich similar to that of bacterial flavodoxins. FAD is bound in a cleft between domains II and III, while domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein, forming a shallow bowl where domain II resides.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: electron transfer flavoprotein subunit alpha, mitochondrial-like [Cicer arietinum] gi|502143739|ref|XP_004505448.1| | 19 | ||
| – | PREDICTED: electron transfer flavoprotein subunit beta, mitochondrial-like [Glycine max] gi|356535428|ref|XP_003536247.1| | 14 | ||
| – | Electron transfer flavoprotein subunit alpha, mitochondrial; TAIR: AT1G50940.1 electron transfer flavoprotein alpha; Swiss-Prot: sp|Q9C6I6|ETFA_ARATH Electron transfer flavoprotein subunit alpha, mitochondrial; TrEMBL-Plants: tr|I3SFR5|I3SFR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148500 | 19 | ||
| – | Electron transfer flavoprotein subunit alpha; TAIR: AT1G50940.1 electron transfer flavoprotein alpha; Swiss-Prot: sp|Q9C6I6|ETFA_ARATH Electron transfer flavoprotein subunit alpha, mitochondrial; TrEMBL-Plants: tr|I3SFR5|I3SFR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148500 | 24 | ||
| – | Electron transfer flavoprotein subunit alpha; TAIR: AT1G50940.1 electron transfer flavoprotein alpha; Swiss-Prot: sp|Q9C6I6|ETFA_ARATH Electron transfer flavoprotein subunit alpha, mitochondrial; TrEMBL-Plants: tr|I3SFR5|I3SFR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148500 | 19 | ||
| – | Electron transfer flavoprotein subunit beta; TAIR: AT5G43430.1 electron transfer flavoprotein beta; Swiss-Prot: sp|Q9LSW8|ETFB_ARATH Electron transfer flavoprotein subunit beta, mitochondrial; TrEMBL-Plants: tr|I3S6Z0|I3S6Z0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0184100 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01714 | CDD | 1 | 16.67 |