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IPR001465 is a Malate synthase, TIM barrel domain.
<p>This entry represents the TIM barrel domain of malate synthases.</p> <p>Malate synthase (MS) ([ec:2.3.3.9]) catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. There have been identified two isoforms, A and G (MSA and MSG, respectively) that differ in size and is attributed to an inserted α/β domain in MSG that may have regulatory function [[cite:PUB00051135], [cite:PUB00029759]]. MSA and MSG consist of an N-terminal α-helical clasp domain, a central TIM-barrel domain and a C-terminal helical plug domain. In malate synthases, the TIM β/α-barrel fold and the C-terminal helical domain are well conserved and the cleft between them forms the active site [[cite:PUB00051135], [cite:PUB00029759], [cite:PUB00014321]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Malate synthase activity | Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+). | ||
| Biological process | Glyoxylate cycle | A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: malate synthase, glyoxysomal [Glycine max] gi|356563180|ref|XP_003549842.1| | 13 | ||
| – | Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 | 13 | ||
| – | Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00727 | CDD | 1 | 33.33 |