Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR019830 is a Malate synthase, conserved site.
<p>Malate synthase ([ec:2.3.3.9]) catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase has a TIM β/α-barrel fold [[cite:PUB00014321]].</p> <p>Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [[cite:PUB00005643]]. The signature pattern for this entry is to a very conserved region in the central section of the enzyme.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Malate synthase activity | Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+). | ||
| Biological process | Glyoxylate cycle | A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: malate synthase, glyoxysomal [Glycine max] gi|356563180|ref|XP_003549842.1| | 13 | ||
| – | Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 | 13 | ||
| – | Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00727 | CDD | 1 | 33.33 |