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IPR019830

Description

IPR019830 is a Malate synthase, conserved site.

<p>Malate synthase ([ec:2.3.3.9]) catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase has a TIM β/α-barrel fold [[cite:PUB00014321]].</p> <p>Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [[cite:PUB00005643]]. The signature pattern for this entry is to a very conserved region in the central section of the enzyme.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Malate synthase activity Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
Biological process Glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
PREDICTED: malate synthase, glyoxysomal [Glycine max] gi|356563180|ref|XP_003549842.1| 13
Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 13
Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00727 CDD 1 33.33