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IPR006252 is a Malate synthase A.
<p>This entry represents glyoxysomal malate synthases and one of two bacterial forms, designated malate synthase A.</p> <p>Malate synthase and isocitrate lyase are the two characteristic enzymes of the glyoxylate cycle. The glyoxylate cycle allows certain organisms, like plants and fungi, to derive their carbon requirements from two-carbon compounds, by bypassing the two carboxylation steps of the citric acid cycle [[cite:PUB00080574]]. Isocitrate lyase, first catalyzes the aldol cleavage of isocitrate to succinate (an intermediate of the tricarboxylic acid cycle) and glyoxylate. Then malate synthase catalyzes the condensation of acetyl CoA with glyoxylate to yield malate (another intermediate of the tricarboxylic acid cycle) [[cite:PUB00080575]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Malate synthase activity | Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+). | ||
| Biological process | Glyoxylate cycle | A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: malate synthase, glyoxysomal [Glycine max] gi|356563180|ref|XP_003549842.1| | 13 | ||
| – | Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 | 13 | ||
| – | Malate synthase; TAIR: AT5G03860.1 malate synthase; Swiss-Prot: sp|P45458|MASY_SOYBN Malate synthase, glyoxysomal; TrEMBL-Plants: tr|I1MUM7|I1MUM7_SOYBN Malate synthase; Found in the gene: LotjaGi4g1v0223500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00727 | CDD | 1 | 33.33 |