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IPR001708 is a Membrane insertase YidC/ALB3/OXA1/COX18.
<p>This entry includes membrane insertase YidC from bacteria, ALBINO3-like proteins from plants, and mitochondrial membrane insertase OXA1 and cytochrome c oxidase assembly protein COX18 from eukaryotes. They are a group of evolutionarily conserved proteins that function in membrane protein integration and protein complex stabilisation. They share a conserved region composed of five transmembrane regions [[cite:PUB00088304]].</p> <p>YidC is required for the insertion of integral membrane proteins into the membrane. It may also be involved in protein secretion processes [[cite:PUB00088303]]. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminal and a large periplasmic domain, located between TM1 and TM2, that adopts a β-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase [[cite:PUB00050750], [cite:PUB00050682]]. The well-characterised YidC protein from Escherichia coli and its close homologues contain a large N-terminal periplasmic domain ([interpro:IPR028053]). This protein interacts with SecYEG protein-conducting channel and the accessory proteins SecDF-YajC to form the bacterial holo-translocon (HTL) [[cite:PUB00102157]].</p> <p>COX18 is a mitochondrial membrane insertase required for the translocation of the C-terminal of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. It plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilisation of newly synthesised MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2 [[cite:PUB00088300]].</p> <p>OXA1 is a mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. It links mitoribosomes with the inner membrane [[cite:PUB00088299]].</p> <p>Plant ALBINO3-like proteins are required for the insertion of some light harvesting chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid membrane [[cite:PUB00088301], [cite:PUB00088302]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Molecular function | Membrane insertase activity | Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ALBINO3-like protein 1, chloroplastic-like [Glycine max] gi|356569211|ref|XP_003552798.1| | 8 | ||
| – | PREDICTED: ALBINO3-like protein 1, chloroplastic-like [Glycine max] gi|356569211|ref|XP_003552798.1| | 10 | ||
| – | PREDICTED: mitochondrial inner membrane protein OXA1-like [Glycine max] gi|356548765|ref|XP_003542770.1| | 11 | ||
| – | PREDICTED: ALBINO3-like protein 2, chloroplastic-like [Glycine max] gi|356566939|ref|XP_003551682.1| | 7 | ||
| – | PREDICTED: ALBINO3-like protein 2, chloroplastic-like [Glycine max] gi|356566939|ref|XP_003551682.1| | 15 | ||
| – | PREDICTED: inner membrane protein PPF-1, chloroplastic-like [Glycine max] gi|356539022|ref|XP_003537999.1| | 11 | ||
| – | Membrane protein insertase YidC; TAIR: AT3G44370.1 Membrane insertion protein, OxaA/YidC with tetratricopeptide repeat domain-containing protein; Swiss-Prot: sp|Q0WUC5|ALB33_ARATH ALBINO3-like protein 3, mitochondrial; TrEMBL-Plants: tr|K7MUF6|K7MUF6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0483300 | 19 | ||
| – | Membrane protein insertase YidC; TAIR: AT5G62050.1 inner membrane OXA1-like protein; Swiss-Prot: sp|Q42191|OXA1_ARATH Mitochondrial inner membrane protein OXA1; TrEMBL-Plants: tr|K7M0E7|K7M0E7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0178100 | 11 | ||
| – | Mitochondrial inner membrane protein OXA1; TAIR: AT5G62050.1 inner membrane OXA1-like protein; Swiss-Prot: sp|Q42191|OXA1_ARATH Mitochondrial inner membrane protein OXA1; TrEMBL-Plants: tr|A0A0R0J5G3|A0A0R0J5G3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0178200_LC | 7 | ||
| – | Membrane protein insertase YidC; TAIR: AT2G28800.1 63 kDa inner membrane family protein; Swiss-Prot: sp|Q9FY06|PPF1_PEA Inner membrane protein PPF-1, chloroplastic; TrEMBL-Plants: tr|A0A0B2QQI6|A0A0B2QQI6_GLYSO Inner membrane protein PPF-1, chloroplastic; Found in the gene: LotjaGi2g1v0371800 | 11 | ||
| – | Membrane protein insertase YidC; TAIR: AT1G24490.1 OxaA/YidC-like membrane insertion protein; Swiss-Prot: sp|Q9FYL3|ALB31_ARATH ALBINO3-like protein 1, chloroplastic; TrEMBL-Plants: tr|I1MYL3|I1MYL3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0097300 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |