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IPR001738

Source: InterPro

Description

IPR001738 is a Rab protein geranylgeranyltransferase component A.

<p>Rab proteins constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic [[cite:PUB00001266], [cite:PUB00000888]]; C-terminal geranylgeranylation is crucial for their membrane association and function. This post-translational modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit enzyme that contains a catalytic heterodimer and an accessory component, termed Rab escort protein (REP)-1 [[cite:PUB00001266], [cite:PUB00000888]]. REP-1 presents newly-synthesised Rab proteins to the catalytic component, and forms a stable complex with the prenylated proteins following the transfer reaction.</p> <p>cDNA cloning of component A of rat Rab geranylgeranyl transferase (REP) confirms its resemblance to Rab3A guanine nucleotide dissociation inhibitor (GDI) and its identity with the human choroideremia gene product [[cite:PUB00000888]]. A genetic defect in REP underlies human choroideremia. Choroideraemia (or tapetochoroidal dystrophy) is a common form of X-linked blindness characterised by progressive dystrophy of the choroid, retinal pigment epithelium and retina [[cite:PUB00004079], [cite:PUB00001997], [cite:PUB00004775]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005968
Cellular component Rab-protein geranylgeranyltransferase complex A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
Subterm of
GO:0006886
Biological process Intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
Subterm of
Part of
GO:0018344
Biological process Protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0355200.1
– Guanosine nucleotide diphosphate dissociation inhibitor; TAIR: AT3G06540.1 Rab escort protein; Swiss-Prot: sp|Q8LLD4|REP_ARATH Rab escort protein 1; TrEMBL-Plants: tr|I1J8C9|I1J8C9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0355200
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00